Results 71 to 80 of about 166,736,405 (308)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Reports of side effects associated with the use of drugs 1976
, 1977 The National Drugs Advisory Board received 463 reports in all during 1976. From these 844 adverse reactions were recorded associated with the use of drugs during the year. There were 13 cases of drug interactions - these are listed separately.
National Drugs Advisory Board (NDAB)
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Effects of anesthetics on mitochondrial quality control: mechanisms and clinical implications
Anesthesiology and Perioperative ScienceFocus on the implications of common perioperative drugs for mitochondrial quality control and their subsequent impact on the overall physiological condition has been increasing.
Xuxin Tan +4 more
doaj +1 more source
Predicting gastrointestinal drug effects using contextualized metabolic models.
PLoS Computational Biology, 2019 Gastrointestinal side effects are among the most common classes of adverse reactions associated with orally absorbed drugs. These effects decrease patient compliance with the treatment and induce undesirable physiological effects.
Marouen Ben Guebila, Ines Thiele
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Physiological effects of peracetic acid on hydroponic tomato plants
, 2003 Peracetic acid (PAA) has potential as a disinfectant of low environmental impact for glasshouse hydroponic systems and other horticultural applications, but can have phytotoxic effects.
Foyer, C. H. +4 more
core +1 more source
Frontiers in Pharmacology, 2019 Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes.
Alexandre J. S. Ribeiro +14 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Report of side effects associated with the use of drugs 1981
, 1981 The National Drugs Advisory Board received 662 reports during 1981 from which 1264 side-effects were recorded. Of these 33.3% concerned drugs affecting the central nervous system and 27% involved anti-infective drugs. Of the drugs affecting the central
National Drugs Advisory Board (NDAB)
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