Results 91 to 100 of about 927,382 (310)

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in Pharmacology, 2019
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes.
Alexandre J. S. Ribeiro, Brian D. Guth, Brian D. Guth, Michael Engwall, Sandy Eldridge, C. Michael Foley, Liang Guo, Gary Gintant, John Koerner, Stanley T. Parish, Jennifer B. Pierson, Mathew Brock, Khuram W. Chaudhary, Yasunari Kanda, Brian Berridge   +14 more
doaj   +1 more source

Self-Regulation of Breathing as a Primary Treatment for Anxiety [PDF]

, 2015
Understanding the autonomic nervous system and homeostatic changes associated with emotions remains a major challenge for neuroscientists and a fundamental prerequisite to treat anxiety, stress, and emotional disorders.
Barnes, Vernon A., Crawford, Molly W., Harden, Kyler, Ravinder, Jerath   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Steady-state activation and modulation of the synaptic-type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands [PDF]

, 2019
The synaptic α1β2γ2 ...
Akk, Gustav, Burbridge, Ariel B, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Steinbach, Joe Henry   +5 more
core   +1 more source

Dispelling urban myths about default uncertainty factors in chemical risk assessment - Sufficient protection against mixture effects? [PDF]

, 2013
© 2013 Martin et al.; licensee BioMed Central LtdThis article has been made available through the Brunel Open Access Publishing Fund.Assessing the detrimental health effects of chemicals requires the extrapolation of experimental data in animals to human
A Kortenkamp, A Kortenkamp, A Rane, AG Renwick, AG Renwick, AG Renwick, AG Renwick, AJ Lehman, Andreas Kortenkamp, BD Naumann, BD Naumann, BGH Bokkers, CI Bliss, CM Thompson, CS Weil, D Hattis, D Hattis, D Hattis, D Hattis, D Hattis, D Hattis, D Hattis, D Hattis, Danish EPA, DL Glaubiger, DM Sheehan, DW Gaylor, ECETOC, ECETOC, ECHA, EJ Bigwood, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Freireich, ER Homan, European Commission, European Community, F Kalberlah, F Kalberlah, F Kalberlah, G Charnley, G Ginsberg, G Ginsberg, G Ginsberg, G Ginsberg, G Vettorazzi, GA Skowronski, GN Krasovskii, GWM Petersvolleberg, H Boxenbaum, H Carlson-Lynch, HA Tilson, HJ Clewell, HJ Clewell, IPCS, IPCS, IPCS, IPCS, IPCS, IWF Davidson, JC Swartout, JECFA, JEFCA, JEFCA, JL Dorne, JLCM Dorne, K Schneider, K Schneider, K Schneider, K Walton, K Walton, K Walton, K Watanabe, KC Silverman, KEMI, KS Crump, KS Crump, LT Haber, M Dourson, M Faust, M Rennen, M Scholze, ME Meek, ML Dourson, ML Dourson, ML Dourson, National Research Council, National Research Council, Olwenn V Martin, P Griem, PR Gentry, PS Price, R Cooke, R Goble, R Hasegawa, R Hasegawa, R Kroes, R Scheuplein, R Truhaut, RH White, RL Dixon, SC Lewis, SCHER/SCENIHR/SCCS, Scholze Martin, SJS Baird, T Backhaus, TG Vermeire, TG Vermeire, USEPA, W Slob, W Slob, WJJ Hayes   +113 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Some physiological effects of psychotropic drugs. [PDF]

British Journal of Clinical Pharmacology, 1976
I, Oswald, V, Bĕxinová
openaire   +2 more sources

Food allergies in pregnant women: a study of prevalence in expecting mothers and association with neonatal outcomes [PDF]

, 2013
Thesis (M.A.)--Boston UniversityIntroduction: Food allergies, the second most common form of allergic disorders in Western countries, have been on the rise in the US over the past few decades especially in young children.
Seita, Helene M.
core   +1 more source

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]

, 2015
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S., Cameron, Ryan T., Hillert, Ellin-Kristina, MacLeod, Ruth   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source