Results 91 to 100 of about 511,607 (303)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Evolution of world running record performances for men and women: physiological characteristics

Frontiers in Physiology
Running world records (WRs) contain information about physiological characteristics that determine running performance. The progression of WRs over time encode the evolution of these characteristics.
Thorsten Emig, Guillaume Adam
doaj   +1 more source

[Physiological status of the body and prediction of the effectiveness of drug therapy of depression. I. Physiological indicators of the reaction to antidepressive drugs].

Psychiatria polska, 1992
Evaluation of pulse and breathing rhythm, postural muscle tone, mood and simple reaction time to auditory signal were conducted sevenfold in each of 35 patients with endogenous depression during the six weeks of antidepressant administration. Increased pulse and breath rate and improved mood on the third day of treatment differentiates good and poor ...
M, Slusarska, M, Wójcik
openaire   +1 more source

The role of mitochondrial transporters in human physiology and adverse drug effects

, 2023
Commonly prescribed medications often cause off-target mitochondrial dysfunction, but the underlying molecular mechanisms are largely unknown. Mitochondrial transport proteins form a significant class of potential off-targets that remain largely unexplored.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Some physiological effects of psychotropic drugs. [PDF]

British Journal of Clinical Pharmacology, 1976
I, Oswald, V, Bĕxinová
openaire   +2 more sources

Testing for Placebo Effects Using Data from Blinded, Randomized Controlled Trials [PDF]

This paper proposes a test for the existence of placebo effects, as described by the so-called expectancy theory. This theory, which is the dominant medical theory of how placebo effects operate, posits that health outcomes rise in individuals' beliefs ...
Anup Malani
core  

Reproducible and uniform cardiac ischemia: effects of antiarrhythmic drugs

, 1978
The in vivo response of cardiac tissue to ischemia is inherently nonuniform, and as a result the drug effects in the latter are subject to great variability.
C. L. Cotner, L. M. Hondeghem
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Electroconvulsive Therapy in Pregnancy: A Review [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2006
Pregnancy is a period in which changes occur in psychological, physiological and social aspects. The treatment methods for psychiatric disorders in this period show some differences. Psychotropic drugs giyen in pregnancy period may have some side effects
Nihat Alpay, Çağatay Karşıdağ
doaj