Results 101 to 110 of about 511,607 (303)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Noisy Drugs, Placebo Perceptual Effects, Time-Buying Concept, and Markov Blankets in Pharmacology [PDF]
In pharmacology, most drugs are designed to produce specific, predictable effects. However, certain medications exhibit both causal and stochastic (random) effects, leading to outcomes that are not entirely deterministic.
Eslami, A.
core +1 more source
MAGNESIUM DEFICIENCY AND CARDIOVASCULAR DISEASES: TIME TO ACT
Рациональная фармакотерапия в кардиологии, 2015 Progression of cardiovascular disease is often caused by a deficiency of magnesium in the human body. Magnesium belongs to the necessary vital macronutrients providing many physiological and pathological reactions and is involved in the constructive ...
E. I. Trisvetova
doaj +1 more source
PHYSIOLOGY AND THE EFFECT OF SOME DRUGS ON OSTEOCLAST
Journal of Dentistry Indonesia, 2015 The osteoclast cellular process is essential for bone growth, remodeling, and repair, and is, under normal conditions, tightly coupled to the process of bone formation by the osteoblast. It is the balance that determines skeletal mass and shape at any point in time. Some drugs effect the osteoclast formation and differentiation.
openaire +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
, 2013 Seminar transcriptIt was in the very early hours of a February morning in 1977 that I first looked down the microscope and saw yellow fluorescence, characteristic of 5-hydroxytryptamine (5-HT) in frozen sections of Octopus brain. After struggling for two
Overy, C, Tansey, EM
core
Mechanism of Action of Compound-13:an α1-Selective Small Molecule Activator of AMPK [PDF]
, 2014 AMPK is a sensor of cellular energy status and a promising target for drugs aimed at metabolic disorders. We have studied the selectivity and mechanism of a recently described activator, C2, and its cell-permeable prodrug, C13. C2 was a potent allosteric
Hunter, Roger W +34 more
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Machine learning prediction of side effects for drugs in clinical trials
, 2023 Early and accurate detection of side effects is critical for the clinical success of drugs under development. Here, we aim to predict unknown side effects for drugs with a small number of side effects identified in randomized controlled clinical trials ...
Paccanaro, Alberto, Galeano, Diego
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AAS, growth hormone, and insulin abuse: psychological and neuroendocrine effects
Therapeutics and Clinical Risk Management, 2008 Michael R Graham1, Peter Evans2, Bruce Davies1, Julien S Baker11Health and Exercise Science Research Unit, Faculty of Health Sport and Science, University of Glamorgan, Pontypridd, Wales, United Kingdom; 2Royal Gwent Hospital, Newport, Gwent, United ...
Michael R Graham +3 more
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