Results 111 to 120 of about 927,382 (310)
Global implications of evidence ‘biased’ practice: management of the third stage of labour [PDF]
, 2008 Increasing attention is being paid to the promotion of clinical and cost-effective care informed by the highest level of evidence to ensure health outcomes are optimised and access to health care is equitable.
Confidential Enquiry into Maternal and Child Health (CEMACH) +10 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Evolution of world running record performances for men and women: physiological characteristics
Frontiers in PhysiologyRunning world records (WRs) contain information about physiological characteristics that determine running performance. The progression of WRs over time encode the evolution of these characteristics.
Thorsten Emig, Guillaume Adam
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Electroconvulsive Therapy in Pregnancy: A Review [PDF]
Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2006 Pregnancy is a period in which changes occur in psychological, physiological and social aspects. The treatment methods for psychiatric disorders in this period show some differences. Psychotropic drugs giyen in pregnancy period may have some side effects
Nihat Alpay, Çağatay Karşıdağ
doaj
The role of mitochondrial transporters in human physiology and adverse drug effects
, 2023 Commonly prescribed medications often cause off-target mitochondrial dysfunction, but the underlying molecular mechanisms are largely unknown. Mitochondrial transport proteins form a significant class of potential off-targets that remain largely unexplored.
openaire +1 more source
Addiction, Genetics, and Criminal Responsibility [PDF]
, 2006 In light of the abundance of studies focusing on the genetic contributions to addiction, Morse develops a meaningful background on the legal and scientific images of behavior, the disease concept of addiction, and the aspects of addiction for which a ...
Morse, Stephen J.
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
AAS, growth hormone, and insulin abuse: psychological and neuroendocrine effects
Therapeutics and Clinical Risk Management, 2008 Michael R Graham1, Peter Evans2, Bruce Davies1, Julien S Baker11Health and Exercise Science Research Unit, Faculty of Health Sport and Science, University of Glamorgan, Pontypridd, Wales, United Kingdom; 2Royal Gwent Hospital, Newport, Gwent, United ...
Michael R Graham +3 more
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