Results 51 to 60 of about 927,382 (310)

Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood

Medicina, 2023
Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs
Allison B. Reiss, Shelly Gulkarov, Aaron Pinkhasov, Katie M. Sheehan, Ankita Srivastava, Joshua De Leon, Aaron E. Katz   +6 more
doaj   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

Frontiers in Endocrinology, 2022
Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide.
Safaet Alam, Md. Moklesur Rahman Sarker, Md. Moklesur Rahman Sarker, Taposhi Nahid Sultana, Md. Nafees Rahman Chowdhury, Mohammad A. Rashid, Nusrat Islam Chaity, Chao Zhao, Jianbo Xiao, Elsayed E. Hafez, Shah Alam Khan, Isa Naina Mohamed   +11 more
doaj   +1 more source

The cerebrovascular effects of adrenaline, noradrenaline and dopamine infusions under propofol and isoflurane anaesthesia in sheep [PDF]

, 2002
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsInfusions of catecholamines are frequently administered to patients receiving propofol or isoflurane anaesthesia.
Fortin D., Motulsky H., Runciman W.B., Stephan H., Teasdale G., Tuor U.I.   +5 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

iScience
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr   +10 more
doaj   +1 more source

Etiology and Management of Sexual Dysfunction [PDF]

, 2009
Sexual dysfunction is the impairment or disruption of any of the three phases of normal sexual functioning, including loss of libido, impairment of physiological arousal and loss, delay or alteration of orgasm.
Bevinahalli Nanjegowda, Raveesh, Muthugaduru Shivarudrappa, Narendra Kumar, Mysore Nagaraj, Anil Kumar, Pai, Nagesh Brahmavar, Rajagopal, Rajendra, Siddika, Nayeema   +5 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Lacosamide and Levetiracetam Have No Effect on Sharp-Wave Ripple Rate

Frontiers in Neurology, 2017
Pathological high-frequency oscillations are a novel marker used to improve the delineation of epileptogenic tissue and, hence, the outcome of epilepsy surgery.
Jan Kudlacek, Jan Kudlacek, Jan Chvojka, Jan Chvojka, Antonin Posusta, Lubica Kovacova, Seung Bong Hong, Seung Bong Hong, Shennan Weiss, Kamila Volna, Petr Marusic, Jakub Otahal, Premysl Jiruska   +12 more
doaj   +1 more source