Results 31 to 40 of about 166,736,405 (308)

Adverse effects of new antiepileptic drugs

, 2004
Starting with phenobarbital in the 1900s, it took almost 70-80 years to introduce old-generation agents for the treatment of epilepsy. Then, in eleven years, nine more new antiepileptic drugs were added to the armamentarium.
Onat, F., Ozkara, C., Onat, F, Ozkara, C
core   +2 more sources

Effects of novel antidepressant drugs on mesenchymal stem cell physiology

Biomedicine & Pharmacotherapy, 2019
It is known that users of psychotropic drugs often have weight gain, adverse effects on bone mineral density and osteoporosis, but the molecular basis for these side effects is poorly understood. The aim of this study is to evaluate the effects in vitro of duloxetine (a serotonin and norepinephrine reuptake inhibitor) and fluoxetine (a selective ...
Ferroni, Letizia, Gardin, Chiara, Bellin, Gloria, Vindigni, Vincenzo, Pavan, Chiara, Zavan, Barbara   +5 more
openaire   +4 more sources

Effects of Antidepressant Drugs on the Behavioral and Physiological Responses to Lipopolysaccharide (LPS) in Rodents [PDF]

Neuropsychopharmacology, 2001
Antidepressants produce various immunomodulatory effects, as well as an attenuation of the behavioral responses to immune challenges, such as lipopolysaccharide (LPS). To explore further the effects of antidepressants on neuroimmune interactions, rats were treated daily with either fluoxetine (Prozac) or saline for 5 weeks, and various behavioral ...
R, Yirmiya, Y, Pollak, O, Barak, R, Avitsur, H, Ovadia, M, Bette, E, Weihe, J, Weidenfeld   +7 more
openaire   +2 more sources

Safety and Effectiveness of a High‐Dose, Tailored Tissue Plasminogen Activator Therapy Protocol: A Joint Pediatric Hematology and Cardiac ICU Quality Improvement Initiative Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric thromboembolism is increasingly encountered in critical care. Systemic thrombolysis with tissue plasminogen activator (tPA) facilitates vessel or valve patency, yet pediatric‐specific protocols remain undefined, and safety concerns persist. Objective To evaluate the efficacy and safety of a tailored, prolonged systemic tPA
Eran Shostak, Oded Gilad, Yael Feinstein, Sigal Nakav, Ofer Schiller, Joanne Yacobovich   +5 more
wiley   +1 more source

Reports of side effects associated with the use of drugs 1991 [PDF]

, 1991
In order that drugs for therapeutic use should be given under the best and safest circumstances, it is important that practitioners be aware of potential hazards in their use.
National Drugs Advisory Board (NDAB)
core  

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

Biomolecules, 2020
Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early ...
Ewelina Zaorska, Lenka Tomasova, Dominik Koszelewski, Ryszard Ostaszewski, Marcin Ufnal   +4 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Instrumentalising therapeutic and enhancement drugs as pharmacological technologies with politicogenic drug effects

, 2022
This paper continues to develop ‘drugs as instruments’ framework by reviewing Science and Technology Studies (STS), critical drug studies and anthropology of pharmaceuticals literature that frames drugs as pharmacological technologies.
Hupli, Aleksi
core   +1 more source

Experimental factors that impact CaV1.2 channel pharmacology—Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the “step-step-ramp” voltage protocol

PLoS ONE, 2022
Background and purpose CaV1.2 channels contribute to action potential upstroke in pacemaker cells, plateau potential in working myocytes, and initiate excitation-contraction coupling.
Ming Ren, Aaron L. Randolph, Claudia Alvarez-Baron, Donglin Guo, Phu N. Tran, Nicolas Thiebaud, Jiansong Sheng, Jun Zhao, Wendy W. Wu   +8 more
doaj   +2 more sources

On-Target Side Effects of Targeted Therapeutics of Cancer

Pathology and Oncology Research, 2022
The concept of precision medicine is based on the identification of hallmarks of cancer to exploit them as drug targets. The basic idea was that in this way the therapeutic modalities will be more effective and the side effects will be less.
József Tímár, Andrea Uhlyarik
doaj   +1 more source