Results 11 to 20 of about 166,736,405 (308)

Dietary nitrate reduces skeletal muscle oxygenation response to physical exercise : a quantitative muscle functional MRI study [PDF]

open access: yes, 2014
© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc.
Gray, Stuart R   +12 more
core   +1 more source

Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development [PDF]

open access: yesAAPS PharmSciTech, 2021
Pediatric drug development faces many difficulties. Traditionally, pediatric drug doses are simply calculated linearly based on the body weight, age, and body surface area of adults. Due to the ontogeny of children, this simple linear scaling may lead to drug overdose in pediatric patients.
Kefei Wang   +5 more
openaire   +2 more sources

Direct but no transgenerational effects of decitabine and vorinostat on male fertility. [PDF]

open access: yesPLoS ONE, 2015
Establishment and maintenance of the correct epigenetic code is essential for a plethora of physiological pathways and disturbed epigenetic patterns can provoke severe consequences, e.g. tumour formation.
Ruth Kläver   +10 more
doaj   +1 more source

Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test Efeitos antidepressivos da duloxetina e da amitriptilina no teste do nado forçado em ratos

open access: yesActa Cirúrgica Brasileira, 2008
PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming ...
Honório Sampaio Menezes   +7 more
doaj   +1 more source

Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test Efeitos antidepressivos da duloxetina e da fluoxetina no teste do nado forçado em ratos

open access: yesActa Cirúrgica Brasileira, 2007
PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming ...
Leandro Ciulla   +5 more
doaj   +1 more source

Allowed Drugs in Children’s Sports: Results of a Survey Among Sports Doctors

open access: yesПедиатрическая фармакология, 2015
Relevance. The reception of various vitamin and mineral supplements, dietary supplements and other approved drugs, which enhance physiological capacities of the body, helps to achieve good results in sports.Object of the survey: to study the opinion of ...
E. G. Vershinin, V. V. Delaryu
doaj   +1 more source

The attitudes of young people to the non-use or use of drugs and to drugs education and prevention strategies [PDF]

open access: yes, 1995
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The study explores the attitudes of young people in the later years of their secondary education to the non-use or use of drugs and to the drugs education ...
Twigg, Barry
core   +7 more sources

Suicidal behavior and antiepileptic drugs in epilepsy: analysis of the emerging evidence [PDF]

open access: yes, 2011
Marco Mula1, Dale C Hesdorffer21Department of Clinical and Experimental Medicine, Amedeo Avogadro University and Division of Neurology, University Hospital Maggiore della Carità, Novara, Italy; 2Gertrude H Sergievsky Center and Department of ...
Mula M   +3 more
core   +1 more source

Prediction of PPAR-α ligand-mediated physiological changes using gene expression profiles

open access: yesJournal of Lipid Research, 2004
Peroxisome proliferator-activated receptor (PPAR)-α controls the transcription of a variety of genes involved in lipid metabolism and is the target receptor for the hypolipidemic drug class of fibrates.
Klaus Stensgaard Frederiksen   +5 more
doaj   +1 more source

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

open access: yesMolecules, 2023
Imidazothiazole derivatives are becoming increasingly important in therapeutic use due to their outstanding physiological activities. Recently, applying imidazothiazole as the core, researchers have synthesized a series of derivatives with biological ...
Mu Guo, Xiangbin Yu, Yi Zhun Zhu, Yue Yu
doaj   +1 more source

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