Results 11 to 20 of about 927,382 (310)
The effect of combined glutamate receptor blockade in the NTS on the hypoxic ventilatory response in awake rats differs from the effect of individual glutamate receptor blockade. [PDF]
, 2014 Ventilatory acclimatization to hypoxia (VAH) increases the hypoxic ventilatory response (HVR) and causes persistent hyperventilation when normoxia is restored, which is consistent with the occurrence of synaptic plasticity in acclimatized animals ...
Carr, John A +3 more
core +2 more sources
Arquivos Brasileiros de Cardiologia, 2010 Os anti-inflamatórios não esteroides (AINEs) encontram-se entre os medicamentos mais prescritos em todo o mundo. Essa classe heterogênea de fármacos inclui a aspirina e vários outros agentes inibidores da ciclo-oxigenase (COX), seletivos ou não. Os AINEs
Michel Batlouni
doaj +1 more source
Nanodrugs alleviate acute kidney injury: Manipulate RONS at kidney
Bioactive Materials, 2023 Currently, there are no clinical drugs available to treat acute kidney injury (AKI). Given the high prevalence and high mortality rate of AKI, the development of drugs to effectively treat AKI is a huge unmet medical need and a research hotspot. Although
Qiaohui Chen +11 more
doaj +1 more source
Pharmacology and clinical drug candidates in redox medicine [PDF]
, 2015 SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I +11 more
core +3 more sources
The effects of estrogen on targeted cancer therapy drugs
Pharmacological Research, 2022 Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex hormone that not only promotes the development of female secondary sexual characteristics, but also supports many important physiological functions.
Ying Zhao +4 more
doaj +1 more source
Selective COX-2 inhibitors and risk of myocardial infarction [PDF]
, 2005 Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids.
Klauss, V. +3 more
core +1 more source
Direct but no transgenerational effects of decitabine and vorinostat on male fertility. [PDF]
PLoS ONE, 2015 Establishment and maintenance of the correct epigenetic code is essential for a plethora of physiological pathways and disturbed epigenetic patterns can provoke severe consequences, e.g. tumour formation.
Ruth Kläver +10 more
doaj +1 more source
Drug release from matrix tablets: physiological parameters and the effect of food [PDF]
Expert Opinion on Drug Delivery, 2014 As dissolution plays an important and vital role in the drug-delivery process of oral solid dosage forms, it is, therefore, essential to critically evaluate the parameters that can affect this process.The consumption of food as well as the physiological environment and properties of the gastrointestinal tract, such as its volume and composition of ...
Nokhodchi, Ali, Asare-Addo, Kofi
openaire +2 more sources
Acta Cirúrgica Brasileira, 2008 PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming ...
Honório Sampaio Menezes +7 more
doaj +1 more source
Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. [PDF]
, 2018 The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female.
Abe +111 more
core +2 more sources