Modelling the behaviour of physiological processes: On the lack of a scientific basis in medical science [PDF]
Communicative & Integrative BiologyPhysiological regulation is extremely complex and cannot be described by homeostasis, the mathematical model generally used in medical science. Homeostasis is based on assumptions which have never been tested or substantiated and when simulated appears ...
Abraham Peper
doaj +2 more sources
Bradycardia, Hyperkalemia, Renal Dysfunction, and Hypoglycemia in Guideline-Directed Medical Therapy for Heart Failure: When to Tolerate and When to Worry [PDF]
Reviews in Cardiovascular MedicineA paradox persists in contemporary heart failure (HF) care, whereby the therapies most clearly proven to save the most lives are also those most frequently interrupted, often for reasons that are more physiological than pathological.
Maria Giulia Bellicini
doaj +2 more sources
Advanced Biomedical Research, 2022 Background: Due to the contradictory results of the effects of Vitamin B6 in reducing the hematotoxic effects of linezolid, the present study aimed to investigate the possible role of Vitamin B6 administration in reducing linezolid-related hematological ...
Kiana Shirani +5 more
doaj +1 more source
Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models
Veterinary Sciences, 2023 Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs,
Maria M. Kotova +9 more
doaj +1 more source
Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors. [PDF]
PLoS ONE, 2014 A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for
Caio Maximino +10 more
doaj +1 more source
Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms
Frontiers in Endocrinology, 2023 Long-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth ...
Junying Hua +7 more
doaj +1 more source
Side Effects of Human Drug Use: An Overview of the Consequences of Eels’ Exposure to Cocaine
Fishes, 2023 The widespread use of drugs is a global problem which affects not only humans but also the environment around them, as research is showing the presence of these substances in different environmental matrices, like air, water, and soil.
Luigi Rosati +5 more
doaj +1 more source
Connexin-dependent neuroglial networking as a new therapeutic target [PDF]
, 2017 Astrocytes and neurons dynamically interact during physiological processes, and it is now widely accepted that they are both organized in plastic and tightly regulated networks.
Christian C. Naus +5 more
core +2 more sources
Pharmacokinetics and antinociceptive effects of tramadol and its metabolite O-desmethyltramadol following intravenous administration in sheep [PDF]
, 2015 Although sheep are widely used as an experimental model for various surgical procedures there is a paucity of data on the pharmacokinetics and efficacy of analgesic drugs in this species. The aims of this study were to investigate the pharmacokinetics of
A., Di Salvo +6 more
core +1 more source
Peptides: Prospects for Use in the Treatment of COVID-19
Molecules, 2020 There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in ...
Vladimir Khavinson +4 more
doaj +1 more source