Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models [PDF]
Veterinary Sciences, 2023 Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs,
Maria M. Kotova +9 more
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Predicting the physiological effects of multiple drugs using electronic health record
Computers in Biology and MedicineVarious computational models have been developed to understand the physiological effects of drug-drug interactions, which can contribute to more effective drug treatments.
Hong, Eujin +4 more
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Advanced Biomedical Research, 2022 Background: Due to the contradictory results of the effects of Vitamin B6 in reducing the hematotoxic effects of linezolid, the present study aimed to investigate the possible role of Vitamin B6 administration in reducing linezolid-related hematological ...
Kiana Shirani +5 more
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Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors. [PDF]
PLoS ONE, 2014 A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for
Caio Maximino +10 more
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Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms
Frontiers in Endocrinology, 2023 Long-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth ...
Junying Hua +7 more
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Side Effects of Human Drug Use: An Overview of the Consequences of Eels’ Exposure to Cocaine
Fishes, 2023 The widespread use of drugs is a global problem which affects not only humans but also the environment around them, as research is showing the presence of these substances in different environmental matrices, like air, water, and soil.
Luigi Rosati +5 more
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Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development [PDF]
AAPS PharmSciTech, 2021 Pediatric drug development faces many difficulties. Traditionally, pediatric drug doses are simply calculated linearly based on the body weight, age, and body surface area of adults. Due to the ontogeny of children, this simple linear scaling may lead to drug overdose in pediatric patients.
Kefei Wang +5 more
openaire +2 more sources
Peptides: Prospects for Use in the Treatment of COVID-19
Molecules, 2020 There is a vast practice of using antimalarial drugs, RAS inhibitors, serine protease inhibitors, inhibitors of the RNA-dependent RNA polymerase of the virus and immunosuppressants for the treatment of the severe form of COVID-19, which often occurs in ...
Vladimir Khavinson +4 more
doaj +1 more source
The effects of estrogen on targeted cancer therapy drugs
Pharmacological Research, 2022 Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex hormone that not only promotes the development of female secondary sexual characteristics, but also supports many important physiological functions.
Ying Zhao +4 more
doaj +1 more source
Dietary nitrate reduces skeletal muscle oxygenation response to physical exercise : a quantitative muscle functional MRI study [PDF]
, 2014 © 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc.
Gray, Stuart R +12 more
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