Acta Cirúrgica Brasileira, 2007 PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming ...
Leandro Ciulla +5 more
doaj +1 more source
Predicting Pharmacokinetics of Drugs Using Physiologically Based Modeling—Application to Food Effects [PDF]
The AAPS Journal, 2009 Our knowledge of the major mechanisms underlying the effect of food on drug absorption allows reliable qualitative prediction based on biopharmaceutical properties, which can be assessed during the pre-clinical phase of drug discovery. Furthermore, several recent examples have shown that physiologically based absorption models incorporating biorelevant
N, Parrott +3 more
openaire +2 more sources
Comparison of veterinary drugs and veterinary homeopathy: part 1 [PDF]
, 2017 For many years after its invention around 1796, homeopathy was widely used in people and later in animals. Over the intervening period (1796-2016) pharmacology emerged as a science from Materia Medica (medicinal materials) to become the mainstay of ...
AABEL +128 more
core +6 more sources
Allowed Drugs in Children’s Sports: Results of a Survey Among Sports Doctors
Педиатрическая фармакология, 2015 Relevance. The reception of various vitamin and mineral supplements, dietary supplements and other approved drugs, which enhance physiological capacities of the body, helps to achieve good results in sports.Object of the survey: to study the opinion of ...
E. G. Vershinin, V. V. Delaryu
doaj +1 more source
Effects of novel antidepressant drugs on mesenchymal stem cell physiology
Biomedicine & Pharmacotherapy, 2019 It is known that users of psychotropic drugs often have weight gain, adverse effects on bone mineral density and osteoporosis, but the molecular basis for these side effects is poorly understood. The aim of this study is to evaluate the effects in vitro of duloxetine (a serotonin and norepinephrine reuptake inhibitor) and fluoxetine (a selective ...
Ferroni, Letizia +5 more
openaire +4 more sources
The effects of pioglitazone, a PPARγ receptor agonist, on the abuse liability of oxycodone among nondependent opioid users [PDF]
, 2016 Aims: Activation of PPARγ by pioglitazone (PIO) has shown some efficacy in attenuating addictive-like responses in laboratory animals. The ability of PIO to alter the effects of opioids in humans has not been characterized in a controlled laboratory ...
Alonzo +74 more
core +1 more source
Types and Distribution of Bioactive Polyunsaturated Aldehydes in a Gradient from Mesotrophic to OligotrophicWaters in the Alborán Sea (Western Mediterranean) [PDF]
, 2020 Polyunsaturated aldehydes (PUAs) are bioactive molecules suggested as chemical defenses and infochemicals. In marine coastal habitats, diatoms reach high PUA production levels during bloom episodes.
Bartual Magro, Ana +11 more
core +1 more source
From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?
Molecules, 2023 Imidazothiazole derivatives are becoming increasingly important in therapeutic use due to their outstanding physiological activities. Recently, applying imidazothiazole as the core, researchers have synthesized a series of derivatives with biological ...
Mu Guo, Xiangbin Yu, Yi Zhun Zhu, Yue Yu
doaj +1 more source
Prediction of PPAR-α ligand-mediated physiological changes using gene expression profiles
Journal of Lipid Research, 2004 Peroxisome proliferator-activated receptor (PPAR)-α controls the transcription of a variety of genes involved in lipid metabolism and is the target receptor for the hypolipidemic drug class of fibrates.
Klaus Stensgaard Frederiksen +5 more
doaj +1 more source
A rare case of melanosis of the hard palate mucosa in a patient with chronic myeloid leukemia [PDF]
, 2015 Imatinib Mesylate, also known as Gleevec or ST1-571, is a tyrosine-kinase inhibitor used as the gold standard medication for the chronic myeloid leukemia (CML); Imatinib has indeed deeply revolutionized the CML therapy allowing most patients to have a ...
Bosco, Daniela +4 more
core +3 more sources