Results 21 to 30 of about 511,607 (303)

Direct but no transgenerational effects of decitabine and vorinostat on male fertility. [PDF]

PLoS ONE, 2015
Establishment and maintenance of the correct epigenetic code is essential for a plethora of physiological pathways and disturbed epigenetic patterns can provoke severe consequences, e.g. tumour formation.
Ruth Kläver, Victoria Sánchez, Oliver S Damm, Klaus Redmann, Elisabeth Lahrmann, Reinhild Sandhowe-Klaverkamp, Christian Rohde, Joachim Wistuba, Jens Ehmcke, Stefan Schlatt, Jörg Gromoll   +10 more
doaj   +1 more source

Antidepressant behavioral effects of duloxetine and amitriptyline in the rat forced swimming test Efeitos antidepressivos da duloxetina e da amitriptilina no teste do nado forçado em ratos

Acta Cirúrgica Brasileira, 2008
PURPOSE: To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS: Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming ...
Honório Sampaio Menezes, Bárbara Beatriz Moreira Bueno, Leandro Ciulla, Alexandre Schuh, Fernanda de Freitas Luz, Rafael José Vargas Alves, Milena Pacheco Abegg, Sílvia Letícia Merceo Bacchi Cirino   +7 more
doaj   +1 more source

Antidepressant behavioral effects of duloxetine and fluoxetine in the rat forced swimming test Efeitos antidepressivos da duloxetina e da fluoxetina no teste do nado forçado em ratos

Acta Cirúrgica Brasileira, 2007
PURPOSE: To compare the effects of the antidepressant drugs duloxetine and fluoxetine on depressive behaviors in rodents. METHODS: Eighteen male Wistar rats were given systemic injections of duloxetine, fluoxetine, or saline prior to a Forced Swimming ...
Leandro Ciulla, Honório Sampaio Menezes, Bárbara Beatriz Moreira Bueno, Alexandre Schuh, Rafael José Vargas Alves, Milena Pacheco Abegg   +5 more
doaj   +1 more source

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis [PDF]

, 2012
Background Type 2 diabetes is a risk factor for Alzheimer's disease (AD), most likely linked to an impairment of insulin signalling in the brain. Therefore, drugs that enhance insulin signalling may have therapeutic potential for AD. Liraglutide (Victoza)
Hunter, Kerry, Holscher, Christian, Hunter Kerry, Hölscher Christian, Kerry Hunter, Christian Holscher   +5 more
core   +1 more source

Allowed Drugs in Children’s Sports: Results of a Survey Among Sports Doctors

Педиатрическая фармакология, 2015
Relevance. The reception of various vitamin and mineral supplements, dietary supplements and other approved drugs, which enhance physiological capacities of the body, helps to achieve good results in sports.Object of the survey: to study the opinion of ...
E. G. Vershinin, V. V. Delaryu
doaj   +1 more source

Evaluation of state and trait biomarkers in healthy volunteers for the development of novel drug treatments in schizophrenia. [PDF]

, 2011
Antipsychotic drugs are the mainstay of treatment for schizophrenia but they have little effect on core negative symptoms or cognitive impairment. To meet the deficiencies of current treatments, novel potential compounds are emerging from preclinical ...
Wilkinson, Lawrence Stephen, Deakin, Bill; id_orcid, Simon Killcross, Ettinger, Ulrich, Ettinger, U., Emma Barkus, Bill Deakin, Killcross, Simon, Roiser, Jonathan P., Ivan Koychev, Deakin, B., Ulrich Ettinger, Wilkinson, Lawrence, Deakin, Bill, Jonathan P Roiser, Killcross, Andrew Simon, Barkus, Emma, Roiser, J. P., Barkus, E., Koychev, Ivan, Koychev, I., Lawrence Wilkinson   +21 more
core   +1 more source

From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?

Molecules, 2023
Imidazothiazole derivatives are becoming increasingly important in therapeutic use due to their outstanding physiological activities. Recently, applying imidazothiazole as the core, researchers have synthesized a series of derivatives with biological ...
Mu Guo, Xiangbin Yu, Yi Zhun Zhu, Yue Yu
doaj   +1 more source

Drug release from matrix tablets: physiological parameters and the effect of food [PDF]

Expert Opinion on Drug Delivery, 2014
As dissolution plays an important and vital role in the drug-delivery process of oral solid dosage forms, it is, therefore, essential to critically evaluate the parameters that can affect this process.The consumption of food as well as the physiological environment and properties of the gastrointestinal tract, such as its volume and composition of ...
Nokhodchi, Ali, Asare-Addo, Kofi
openaire   +2 more sources

Prediction of PPAR-α ligand-mediated physiological changes using gene expression profiles

Journal of Lipid Research, 2004
Peroxisome proliferator-activated receptor (PPAR)-α controls the transcription of a variety of genes involved in lipid metabolism and is the target receptor for the hypolipidemic drug class of fibrates.
Klaus Stensgaard Frederiksen, Erik Max Wulff, Per Sauerberg, John Patrick Mogensen, Lone Jeppesen, Jan Fleckner   +5 more
doaj   +1 more source

A New Frontier in Epilepsy: Novel Antiepileptogenic Drugs

Journal of Pharmacological Sciences, 2006
.: Epilepsy is a hetergenous syndrome characterized by recurrently and repeatedly occurring seizures. Although able to inhibit the epileptic seizures, the currently available antiepileptic drugs (AEDs) have no effects on epileptogenesis. Such AEDs should
Masashi Sasa
doaj   +1 more source