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Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Treat me well: Affective and physiological feedback for wheelchair users [PDF]
This work reports a electrocardiograph and skin conductivity hardware architecture, based on E-textile electrodes, attached to a wheelchair for affective and physiological computing. Appropriate conditioning circuits and a microcontroller platform that performs acquisition, primary processing, and communication using Bluetooth were designed and ...
Octavian Postolache +5 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On the global attractor of delay differential equations with unimodal feedback [PDF]
We give bounds for the global attractor of the delay differential equation x(over dot) (t) = -mu x(t) + f(x(t - tau)), where f is unimodal and has negative Schwarzian derivative.
Liz, Eduardo +3 more
core +1 more source
A preliminary investigation into student writers’ perception of corrective feedback focus [PDF]
The purpose of this study is to investigate whether second language student writers’ perception or lack of perception of targeted error type influences corrective feedback effectiveness.
Chian-Wen Kao
core +1 more source
The human gut microbiome across the life course
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Multimodal measurements enhance insights into emotional responses to immediate feedback
Adaptive learning technologies often provide students with immediate feedback on task performance. This feedback can elicit various emotional responses, which, in turn, influence learning. Most recent studies capture these emotions by single data streams,
Anne Horvers +4 more
doaj +1 more source
The feeling of agency: Empirical indicators for a pre-reflective level of action awareness
The sense of agency has been defined as the sense that I am the author of my own actions. This sense, however, is usually not reflected upon but instead pre-reflectively experienced.
Nicole eDavid +4 more
doaj +1 more source

