Results 51 to 60 of about 2,517,379 (288)

A balance equation determines a switch in neuronal excitability. [PDF]

PLoS Computational Biology, 2013
We use the qualitative insight of a planar neuronal phase portrait to detect an excitability switch in arbitrary conductance-based models from a simple mathematical condition. The condition expresses a balance between ion channels that provide a negative
Alessio Franci, Guillaume Drion, Vincent Seutin, Rodolphe Sepulchre   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Feedback systems as interferers in perfectionism: a systematic literature review

Frontiers in Psychiatry
BackgroundPerfectionism is a multidimensional construct characterized by the striving for exceptionally high standards and critical self-evaluation. It can manifest in both adaptive and maladaptive forms.
Adel Bartos, Adel Bartos, Monika Marosi, Istvan Karsai, Kristof Schwartz   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

How Does Plant CO2 Physiological Forcing Amplify Amazon Warming in CMIP6 Earth System Models?

Earth's Future
The physiological response to increasing CO2 concentrations will lead to land surface warming through a redistribution of the energy balance. As the Amazon is one of the most plant‐rich regions, the increase in surface temperature, caused by plant CO2 ...
Haechan Kimm, So‐Won Park, Sang‐Yoon Jun, Jong‐Seong Kug   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ubiquitous Biofeedback Serious Game for Stress Management

IEEE Access, 2016
Serious games augment utilitarian applications with an entertainment dimension. Hence, information pertaining to a utilitarian objective is seamlessly incorporated into the gaming scenario.
Hussein Al Osman, Haiwei Dong, Abdulmotaleb El Saddik   +2 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Understanding negative feedback and classical conditioning of autonomic responses in physiological regulation

Frontiers in Physiology
Physiological regulation is achieved via a complex and highly integrated network of innate autonomic and somatic reflexes combined with learned responses acquired through experience.
Douglas S. Ramsay, Stephen C. Woods
doaj   +1 more source

A Survey on Psycho-Physiological Analysis & Measurement Methods in Multimodal Systems

Multimodal Technologies and Interaction, 2019
Psycho-physiological analysis has gained greater attention in the last few decades in various fields including multimodal systems. Researchers use psychophysiological feedback devices such as skin conductance (SC), Electroencephalography (EEG) and ...
Muhammad Zeeshan Baig, Manolya Kavakli
doaj   +1 more source