Results 101 to 110 of about 6,434,349 (320)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Application of a Flow-Induced Stress Wave and Investigation of Associated Injuries on Cell Monolayers Using a Parallel Plate Flow Chamber

Methods and Protocols, 2020
Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications usually involve the generation of continuous and steady fluid flow over cell monolayers for ...
Samar Shurbaji, Mahmoud Khatib A. A. Al-Ruweidi, Fatma Hassan Ali, Fatiha M. Benslimane, Huseyin C. Yalcin   +4 more
doaj   +1 more source

Mass Energy and Flow in closed ecosystems [PDF]

, 1972
The general equations of biomass and energy transfer for an n-species, closed ecosystem are written. It is demonstrated how in "ecological time" the parameters describing the dynamics of biomass transfer are related to the parameters of energy transfer ...
Ulanowicz, Robert
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A novel tube law analysis under anisotropic external load

Scientific Reports
Mathematical and physical modeling of flows in collapsible pipes often relates the flow area to the difference between the internal and the external pressures (i.e. the transmural pressure).
Lorenzo Lotti, Costanza Carbonari, Giulio Calvani, Enio Paris   +3 more
doaj   +1 more source

Effects of aggregation on the blood flow velocity field measured by a μPIV based technique [PDF]

, 2009
This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009), Balabani, S, Dusting, J, Kaliviotis, E   +3 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The effects of flow settings during high-flow nasal cannula oxygen therapy for neonates and young children

European Respiratory Review
Background During neonatal and paediatric high-flow nasal cannula therapy, optimising the flow setting is crucial for favourable physiological and clinical outcomes.
Jie Li, Ni Deng, Wan Jia Aaron He, Cui Yang, Pan Liu, Fai A. Albuainain, Brian J. Ring, Andrew G. Miller, Alexandre T. Rotta, Robert D. Guglielmo, Christophe Milési   +10 more
doaj   +1 more source

Flow and particle deposition using an integrated CFD model of the respiratory system [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Alexopoulos, AH, Karakosta, P, Kiparissides, C   +3 more
core  

Optimal villi density for maximal oxygen uptake in the human placenta

, 2015
We present a stream-tube model of oxygen exchange inside a human placenta functional unit (a placentone). The effect of villi density on oxygen transfer efficiency is assessed by numerically solving the diffusion-convection equation in a 2D+1D geometry ...
Brownbill, P., Filoche, M., Grebenkov, D. S., Salafia, C., Serov, A. S.   +4 more
core   +1 more source