Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Does therapeutic massage support mental well-being? [PDF]
Massage was once a traditional medical practice of many ancient cultures. Today, the practice of modern therapeutic massage is embedded within the field of complementary or alternative medicine (CAM).
Cavaye, Joyce
core +1 more source
The ecology of exercise: mechanisms underlying Individual variation in behavior, activity, and performance: an introduction to symposium [PDF]
Wild animals often engage in intense physical activity while performing tasks vital for their survival and reproduction associated with foraging, avoiding predators, fighting, providing parental care, and migrating.
Auer +116 more
core +1 more source
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Effects of clonal fragmentation on Pyrrosia nuda depend on growth stages in a rubber plantation
IntroductionClonal fragmentation helps to assess clonal plants' growth resilience to human and environmental disturbance. Although clonal integration in epiphytes in tropical rubber plantations is important to understand their role in enhancing ...
Xiaocheng Yu +19 more
doaj +1 more source
Integrating the inputs that shape pancreatic islet hormone release. [PDF]
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Does physiological integration among intraclonal ramets of Iris pumila enhance stress tolerance in heterogeneous environments? [PDF]
We tested the hypothesis that sharing essential resources through interconnected ramets increases stress tolerance of a clonal plant in patchy environments.
Manitašević-Jovanović Sanja +2 more
doaj +1 more source
Physiology in Perspective: The Value of Integrative Physiology [PDF]
Almost a year ago, I gained a close and personal appreciation for the value gained from an understanding of integrative physiology. Suddenly one morning, while on vacation, I was struck by a massive pulmonary embolism and experienced first hand the importance of the interaction between the ...
openaire +2 more sources
Fluid-structure interaction simulation of pulse propagation in arteries : numerical pitfalls and hemodynamic impact of a local stiffening [PDF]
When simulating the propagation of a pressure pulse in arteries, the discretization parameters (i.e. the time step size and the grid size) need to be chosen carefully in order to avoid a decrease in amplitude of the traveling wave due to numerical ...
Degroote, Joris +4 more
core +1 more source

