Miniature inhibitory postsynaptic current in cerebellar Purkinje cells of old dystrophic mdx mice
, 2018 Duchenne muscular dystrophy (DMD) is caused by the mutations in the X-linked dystrophin gene resulting in a deficiency in the protein dystrophin. About 1/3 of boys with DMD display some degree of cognitive impairments (Cotton et al., 2001).
Tan, Chek Ying (S33333) +3 more
core
Flash photolysis of caged compounds: casting light on physiological processes
, 1998 Photorelease of bioactive molecules from inactive precursors is a very powerful tool for the study of the molecular mechanisms underlying physiological processes as diverse as ionic channel modulation, exocytosis, phototransduction, ligand-receptor ...
Landò L +6 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Germination Performance of Physalis peruviana L. Seeds under Thermal and Water Stress Conditions
AgronomyPhysalis peruviana holds significant economic value, making it crucial to determine optimal cultivation conditions, particularly concerning seed germination under varying water and temperature conditions. Therefore, this study aimed to assess the impacts
Elis Marina de Freitas +3 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Cannabinoid receptor 2 expression in proximal tubule cells exposed to elevated glucose and albumin
, 2012 Introduction. Hyperglycaemia plays a significant role in the aetiology of diabetic nephropathy. Compounded with this, renal tubule cells are also exposed to high levels of albumin in the filtrate, which is caused by damage to the glomerulus.
McAinch, Andrew J. +2 more
core
Editorial: Physiology and Clinical Potential of Eccentric Exercise [PDF]
Frontiers in Physiology, 2017 Martino V. Franchi +5 more
openaire +5 more sources
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Dimensionality Reduction Techniques for the Analysis of Physiological Signals in Human Sexual Response [PDF]
openThis thesis explores the physiological signals that underlie the sexual response of women, focusing on the identification of the orgasm phase.
CHINELLO, ANGELA
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source