Results 151 to 160 of about 1,856,828 (312)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Physiological and perceptual responses during self-regulated exercise in children with cystic fibrosis [PDF]

, 2011
Purpose: To examine the physiological and perceptual responses during self-regulated exercise in children with cystic fibrosis (CF). Methods: Twelve children (10.8 ± 2.0 y) with CF made 3 separate visits to the research laboratory in the school of ...
Britton, Fionnuala
core  

A Multi-Epiphysiological Indicator Dog Emotion Classification System Integrating Skin and Muscle Potential Signals

Animals
This study introduces an innovative dog emotion classification system that integrates four non-invasive physiological indicators—skin potential (SP), muscle potential (MP), respiration frequency (RF), and voice pattern (VP)—with the extreme gradient ...
Wenqi Jia, Yanzhi Hu, Zimeng Wang, Kai Song, Boyan Huang   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Aversiveness of sound in marine mammals : psycho-physiological basis, behavioural correlates and potential applications

, 2010
Understanding what psycho-physiological and behavioural factors influence aversiveness of sound in marine mammals is important for conservation and practical applications.
Götz, Thomas
core  

Response latency of a motion-sensitive neuron in the fly visual system: dependence on stimulus parameters and physiological conditions

, 2000
Warzecha A-K, Egelhaaf M. Response latency of a motion-sensitive neuron in the fly visual system: dependence on stimulus parameters and physiological conditions. Vision research.
Egelhaaf, Martin, Anne-Kathrin Warzecha, Egelhaaf, Martin ; https://orcid.org/, Martin Egelhaaf, Warzecha, Anne-Kathrin   +4 more
core   +1 more source

Classification of artificially aged lentil seeds using Fourier transform near-infrared spectroscopy

Pesquisa Agropecuária Tropical
Seed deterioration is among the main causes of loss in physiological potential. This study aimed to investigate the potential of Fourier transform near-infrared (FT-NIR) spectroscopy to classify lentil seeds subjected to artificial aging at 41 ºC and 100
Marcelo Augusto Rocha Limão, Daniel Teixeira Pinheiro, André Dantas de Medeiros, João Paulo Oliveira Ribeiro, Denise Cunha Fernandes dos Santos Dias, Laércio Junio da Silva   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Potential physiological and pathophysiological roles for protease-activated receptor-2 in the kidney

, 2007
The protease-activated receptor-2 (PAR-2), the second of four members of a unique subfamily of G-protein coupled receptors, is abundantly expressed in the kidney.
Gobe, Glenda C., Hooper, John D., Johnson, David W., Vesey, David A.   +3 more
core   +1 more source