Results 141 to 150 of about 1,856,828 (312)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Selective inhibition of physiological late Na+ current stabilizes ventricular repolarization
, 2018 The physiological role of cardiac late Na+ current ( INa) has not been well described. In this study, we tested the hypothesis that selective inhibition of physiological late INa abbreviates the normal action potential (AP) duration (APD) and ...
Gong-Xin Liu +4 more
core +1 more source
Germination Performance of Physalis peruviana L. Seeds under Thermal and Water Stress Conditions
AgronomyPhysalis peruviana holds significant economic value, making it crucial to determine optimal cultivation conditions, particularly concerning seed germination under varying water and temperature conditions. Therefore, this study aimed to assess the impacts
Elis Marina de Freitas +3 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Effect of altering the number of players, the dimensions of the playing area and the playing rules on the number of selected technical skills performed, possession characteristics, physiological responses and levels of enjoyment and perceived competence during gaelic football in prepubescent and adolescent boys [PDF]
, 2011 Small sided games have been advocated as an alternative to traditional 15-a-side Gaelic football games for children. Three studies were undertaken to compare the number and types of skills performed, possession characteristics
Whelan, Michael
core
Wearable physiological sensors and real-time algorithms for detection of acute mountain sickness
, 2018 This is a minireview of potential wearable physiological sensors and algorithms (process and equations) for detection of acute mountain sickness (AMS).
Stephen R. Muza
core +1 more source
Editorial: Physiology and Clinical Potential of Eccentric Exercise [PDF]
Frontiers in Physiology, 2017 Martino V. Franchi +5 more
openaire +5 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source