Results 231 to 240 of about 1,856,828 (312)

Selenoneine, a food chain component with potential neuroprotective effects against electrophilic mercury forms. [PDF]

Adv Neurotoxicol
Rieder GS, Zeppilli D, Nogara PA, Aschner M, Tinkov AA, Adedara IA, de Souza DOG, de Souza DG, Orian L, Rocha JBT.   +9 more
europepmc   +1 more source

Illuminating Potential Harms of the Physiologic Futility Standard

The American Journal of Bioethics
Julia K. Axelrod, Sofia Weiss Goitiandia, Jason N. Batten, Teva D. Brender, Elizabeth Dzeng   +4 more
openaire   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Using Heart Rate to Measure Stress in Healthcare Workers Wearing PAPRs and N95 Masks: Insights from a Randomized Trial. [PDF]

Sensors (Basel)
Almeida RMA, Maciel RR, Moraes CHV, Ciofi-Silva CL, Oliveira NA, Mainardi GM, Cordeiro L, Levin ASS, Price AI, Lin YL, Padoveze MC.   +10 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Effects of different menthol administration routes on endurance performance and physiological responses in the heat: a network meta-analysis. [PDF]

Front Nutr
Zhu Y, Zhao J, Yao J, Wang H, Yuan X.
europepmc   +1 more source