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Physiological-based pharmacokinetic modeling of endotoxin in the rat
Toxicology and Industrial Health, 2012We have previously measured the distribution and pharmacokinetics of biosynthetically radiolabeled endotoxin of Salmonella typhimurium following intraperitoneal (IP) dosing (200 μg/kg) in Sprague-Dawley rats. In our experiments, the fatty acid residues were labeled with 3 H and the ...
Joseph C, Hutter, Chung S, Kim
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Physiologically Based Pharmacokinetic Modeling
2005Preface. Acknowledgments. Contributors. Chapter 1. Introduction: A Historical Perspective of the Development and Applications of PBPK Models. 1. Introduction. 2. A Historical Perspective. 2-1. Responses to Inhaled Compounds. 2-2. Pharmaceutical Applications. 2-3. Occupational and Environmental Applications. 2-4. Digital Computation and PBPK Modeling. 3.
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Whole-body physiologically based pharmacokinetic models
Expert Opinion on Drug Metabolism & Toxicology, 2007This review summarizes the most recent developments in and applications of physiologically based pharmacokinetic (PBPK) modeling methodology originating from both the pharmaceutical and environmental toxicology areas. It focuses on works published in the last 5 years, although older seminal papers have also been referenced.
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Physiologically based pharmacokinetic modelling of cefoperazone in paediatrics
British Journal of Clinical PharmacologyAimsCefoperazone is commonly used off‐label in the treatment of bacterial meningitis and sepsis in children, and the pharmacokinetic (PK) data are limited in this vulnerable population. The goal of this study was to develop a physiologically based pharmacokinetic (PBPK) model to predict pediatric cefoperazone exposure for rational dosing ...
Qiushi Wang +4 more
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Physiologically-based pharmacokinetic modeling of pyrene in the rat
Environmental Toxicology and Pharmacology, 1998The objective of the present study was to develop a physiologically-based model to simulate the oral and i.v. pharmacokinetics of pyrene in the rat. The physiologically-based pharmacokinetic (PBPK) model for pyrene consisted of the following tissue compartments: liver, lungs, adipose tissue, slowly perfused tissues, and richly perfused tissues ...
S, Haddad +4 more
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Physiologically Based Pharmacokinetic (PBPK) Modeling in Children
Clinical Pharmacology & Therapeutics, 2012This review summarizes the present status of physiologically based pharmacokinetic (PBPK) modeling and simulation (M&S) and its application in support of pediatric drug research. We address the reasons that PBPK is suited to the current needs of pediatric drug development and pharmacotherapy in light of the evolution in pediatric PBPK methodologies and
J S, Barrett +3 more
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Physiological Parameter Values for Physiologically Based Pharmacokinetic Models
Toxicology and Industrial Health, 1997R P, Brown +4 more
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Physiologically Based Pharmacokinetic Models in Developmental Toxicology
Risk Analysis, 1994The kinetics of disposition of drugs and environmental chemicals will be altered as a result of the rapid and pronounced anatomic and physiologic changes that occur during pregnancy. These include changes in maternal intestinal motility, pulmonary tidal volume and minute volume, cardiac output, and renal function as well as in maternal tissue and fluid
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International Journal of Environmental Research and Public Health, 2023
Deepika Deepika, Vikas Kumar
exaly
Deepika Deepika, Vikas Kumar
exaly