Results 1 to 10 of about 130,197 (208)
Nanomaterials, 2020 There have been efforts to develop physiologically based pharmacokinetic (PBPK) models for nanomaterials (NMs). Since NMs have quite different kinetic behaviors, the applicability of the approaches and techniques that are utilized in current PBPK models ...
Wells Utembe +4 more
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Thrombosis Journal, 2018 Background The EINSTEIN-Jr program will evaluate rivaroxaban for the treatment of venous thromboembolism (VTE) in children, targeting exposures similar to the 20 mg once-daily dose for adults.
Stefan Willmann +9 more
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Theranostics, 2022 Rationale: Physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PK) modelling approaches are widely accepted in non-radiopharmaceutical drug development and research, while there is no major role for these approaches in ...
H. Siebinga +4 more
semanticscholar +1 more source
Pharmaceutics, 2022 Doxorubicin (DOX) is still an important anticancer agent despite its tricky pharmacokinetics (PK) and toxicity potential. The advent of systems pharmacology enables the construction of PK models able to predict the concentration profiles of drugs and ...
George A. Mystridis +2 more
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Clinical Pharmacokinetics, 2022 Background Obese individuals are often underrepresented in clinical trials, leading to a lack of dosing guidance. Objective This study aimed to investigate which physiological parameters and drug properties determine drug disposition changes in obese ...
Mattia Berton +4 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Introduction: Physiologically based pharmacokinetic (PBPK) models for the absorption, disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine in pregnant women (p-PBPK) are rare. The aim of this short research report is
Basile Amice +3 more
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Pharmaceutics, 2023 Microarray patches (MAPs) are currently under investigation as a self-administered, pain-free alternative used to achieve long-acting (LA) drug delivery.
Hannah Kinvig +9 more
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Molecules, 2021 The application of physiologically based pharmacokinetic models to nanoparticles is still very restricted and challenging, owing to the complicated in vivo transport mechanisms involving nanoparticles, including phagocytosis, enhanced permeability and ...
Lei Li +8 more
semanticscholar +1 more source
Personalise vitamin D3 using physiologically based pharmacokinetic modelling
CPT: Pharmacometrics & Systems Pharmacology, 2021 Plasma concentration of vitamin D3 metabolite 25‐hydroxyvitamin D3 (25(OH)D3) is variable among individuals. The objective of this study is to establish an accurate model for 25(OH)D3 pharmacokinetics (PKs) to support selection of a suitable dose regimen
Zhonghui Huang, Tao You
doaj +1 more source
Pharmaceutics, 2023 The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight.
Pieter-Jan De Sutter +4 more
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