Physiologically Based Pharmacokinetic Modelling of Cabotegravir Microarray Patches in Rats and Humans [PDF]
Pharmaceutics, 2023 Microarray patches (MAPs) are currently under investigation as a self-administered, pain-free alternative used to achieve long-acting (LA) drug delivery.
Hannah Kinvig +9 more
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Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling [PDF]
Pharmaceutics, 2023 The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight.
Pieter-Jan De Sutter +4 more
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Physiologically Based Pharmacokinetic Modelling and Simulation to Predict the Plasma Concentration Profile of Doxorubicin [PDF]
Pharmaceutics, 2022 Doxorubicin (DOX) is still an important anticancer agent despite its tricky pharmacokinetics (PK) and toxicity potential. The advent of systems pharmacology enables the construction of PK models able to predict the concentration profiles of drugs and ...
George A. Mystridis +2 more
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Prediction of pediatric dose of tirzepatide from the reference adult dose using physiologically based pharmacokinetic modelling [PDF]
Frontiers in Pharmacology, 2023 Tirzepatide is an emerging hypoglycemic agent that has been increasing used in adults, yet its pharmacokinetic (PK) behavior and dosing regimen in pediatric population remain unclear.
Ruifang Guan +3 more
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Lamivudine and Emtricitabine Dosing Proposal for Children with HIV and Chronic Kidney Disease, Supported by Physiologically Based Pharmacokinetic Modelling [PDF]
Pharmaceutics, 2023 Dose recommendations for lamivudine or emtricitabine in children with HIV and chronic kidney disease (CKD) are absent or not supported by clinical data.
Tom G. Jacobs +7 more
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Physiologically-based pharmacokinetic modelling and dosing evaluation of gentamicin in neonates using PhysPK [PDF]
Frontiers in Pharmacology, 2022 Each year, infections caused around the 25% of neonatal deaths. Early empirical treatments help to reduce this mortality, although optimized dosing regimens are still lacking.
Hinojal Zazo +14 more
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Personalise vitamin D3 using physiologically based pharmacokinetic modelling [PDF]
CPT: Pharmacometrics & Systems Pharmacology, 2021 Plasma concentration of vitamin D3 metabolite 25‐hydroxyvitamin D3 (25(OH)D3) is variable among individuals. The objective of this study is to establish an accurate model for 25(OH)D3 pharmacokinetics (PKs) to support selection of a suitable dose regimen
Zhonghui Huang, Tao You
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Physiologically Based Pharmacokinetic Modelling for Nicotine and Cotinine Clearance in Pregnant Women [PDF]
Frontiers in Pharmacology, 2021 Introduction: Physiologically based pharmacokinetic (PBPK) models for the absorption, disposition, metabolism and excretion (ADME) of nicotine and its major metabolite cotinine in pregnant women (p-PBPK) are rare. The aim of this short research report is
Basile Amice +3 more
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Physiologically Based Pharmacokinetic Modelling to Predict Pharmacokinetics of Enavogliflozin, a Sodium-Dependent Glucose Transporter 2 Inhibitor, in Humans [PDF]
Pharmaceutics, 2023 Enavogliflozin is a sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor approved for clinical use in South Korea. As SGLT2 inhibitors are a treatment option for patients with diabetes, enavogliflozin is expected to be prescribed in various ...
Min-Soo Kim +11 more
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The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling [PDF]
Pharmaceutics, 2022 Background: pathophysiological changes such as low cardiac output (LCO) impact pharmacokinetics, but its extent may be different throughout pediatrics compared to adults. Physiologically based pharmacokinetic (PBPK) modelling enables further exploration.
Karel Allegaert +3 more
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