Results 111 to 120 of about 15,765 (342)
PharmaceuticsBackground/Objectives: Cirrhosis significantly alters physiological function and drug metabolism, particularly for medications primarily metabolized by CYP2C19 and CYP3A4.
Ruijing Mu +5 more
doaj +1 more source
Validation of computational approaches for antiretroviral dose optimization [PDF]
, 2016 Strategies for reducing antiretroviral doses and drug costs can support global access, and numerous options are being investigated. Efavirenz pharmacokinetic simulation data generated with a bottom-up physiologically based model were successfully ...
Dickinson, L, Owen, A, Siccardi, M
core +1 more source
Advanced Healthcare Materials, EarlyView.This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao +8 more
wiley +1 more source
Quantitative systems pharmacology of interferon alpha administration: A multi-scale approach.
PLoS ONE, 2019 The therapeutic effect of a drug is governed by its pharmacokinetics which determine the downstream pharmacodynamic response within the cellular network. A complete understanding of the drug-effect relationship therefore requires multi-scale models which
Priyata Kalra +7 more
doaj +1 more source
Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans [PDF]
, 2009 International audienceParticulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. Recent studies investigated whether and to which extent inhaled ultrafine particles are able to translocate into the bloodstream in
Bois, Frédéric Y. +4 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad +3 more
wiley +1 more source
Design, modelling, and pharmacokinetic prediction of novel BRD4-targeting PROTACs
In Silico Research in BiomedicineBackground: Proteolysis Targeting Chimeras (PROTACs) represent an emerging modality for targeted protein degradation, yet their development is often constrained by suboptimal physicochemical and pharmacokinetic properties.
Bharath BR, S. Jahnavi, Nadeem Khan
doaj +1 more source
Quantitative Risk Analysis for N-Methyl Pyrrolidone Using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling [PDF]
, 2009 Torka S. Poet +5 more
openalex +1 more source
Drug–drug interaction prediction of ziritaxestat using a physiologically based enzyme and transporter pharmacokinetic network interaction model [PDF]
, 2023 Jérémy Perrier +5 more
openalex +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney +3 more
wiley +1 more source