Results 131 to 140 of about 15,765 (342)

Autonomous Hydrogel Actuators Programmed by Endogenous Biochemical Logic for Dual‐Stage Morphing and Drug Release

Advanced Materials, EarlyView.
A 3D‐printed BSA–PEGDA bilayer actuator performs biochemical logic, bending autonomously in acid and releasing its drug payload only when both acid and pepsin are present. This dual‐stage, enzyme‐gated mechanism enables autonomous catch‐and‐release motion and controlled gastric drug delivery, representing a programmable soft material powered by ...
Yuchen Liu, Harischandra Potthuri, Alejandro Sosnik, Luai R. Khoury   +3 more
wiley   +1 more source

P01 Application of feto-placental-maternal physiologically-based pharmacokinetic model to predict tenofovir concentration during pregnancy [PDF]

, 2019
Khaled Abduljalil, TN Johnson, Masoud Jamei   +2 more
openalex   +1 more source

How to integrate in vitro PK/PD information for toxicity prediction [PDF]

, 2009
Predicting drugs' in vivo effects from in vitro testing requires modelling processes that are not reproduced by in vitro systems. The most obvious difference between the two situations is the absence of the absorption, distribution, metabolism, and ...
Bois, Frédéric Y.
core   +1 more source

A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone

, 2010
Recommended standardized procedures for determining exhaled lower respiratory nitric oxide and nasal nitric oxide have been developed by task forces of the European Respiratory Society and the American Thoracic Society.
A Amann, A Amann, AB Lumb, AC Schrikker, AK Mörk, AK Mörk, Anton Amann, AW Jones, AW Jones, C Ammann, C Cobelli, C Warneke, CEW Hahn, CN Tassopoulos, D Angeli, D Smith, D Sonntag, DE Mohrman, E Hairer, E Kuhn, E Wigaeus, ED Sontag, ER McFadden, ER Swenson, G Johanson, G Wang, GA Truskey, GAJ Reichard, Gerald Teschl, GH Golub, H Nijmeijer, Hartmann Hinterhuber, Helin Koc, HJ Clewell, HJ Sussmann, HT Banks, HT Banks, HU Voss, J Herbig, J Ji-Fa, J King, J King, J Ohlsson, J Rieder, J Staudinger, J Stoer, JA Jacquez, JA Jacquez, JB West, JC Anderson, JC Anderson, JC Anderson, JMB Hughes, JT Ottesen, Julian King, JV Beck, KA Cope, Karl Unterkofler, KD Thrall, L Keck, L Lindberg, LE Farhi, LM Hanna, LM Hanna, M Peifer, ME O’Hara, ME Tsu, ME Tsu, MP Kalapos, NR Morris, OB Crofford, OE Owen, P Leenheer, P Scheid, PD Wagner, PD Wagner, PR Galassetti, R Hermann, S Kumagai, S Kumagai, S Kumagai, SK Kundu, Susanne Teschl, T Birken, T Brundin, TB Martonen, TG Müller, U Keller, W Horbelt, W Lindinger, W Lindinger, W Miekisch, Y Wang, YVC Rao   +93 more
core   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Updated <i>in Silico</i> Prediction Methods for Fractions Absorbed and Key Input Parameters of 355 Disparate Chemicals for Physiologically Based Pharmacokinetic Models for Time-Dependent Plasma Concentrations after Virtual Oral Doses in Humans

, 2022
Koichiro Adachi, Makiko Shimizu, Hiroshi Yamazaki   +2 more
openalex   +2 more sources

Materials and System Design for Self‐Decision Bioelectronic Systems

Advanced Materials, EarlyView.
This review highlights how self‐decision bioelectronic systems integrate sensing, computation, and therapy into autonomous, closed‐loop platforms that continuously monitor and treat diseases, marking a major step toward intelligent, self‐regulating healthcare technologies.
Qiankun Zeng, Hong Liu, Yongheng Zhang, Youbin Zheng, Xuyin Ding, Mengni Zhu, Guoyue Shi, Yan Wang, Hossam Haick, Min Zhang   +9 more
wiley   +1 more source

Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

Frontiers in Toxicology
With the use of in vitro new approach methodologies (NAMs) for the assessment of non-combustible next-generation nicotine delivery products, new extrapolation methods will also be required to interpret and contextualize the physiological relevance of ...
Marjory Moreau, Liam Simms, Melvin E. Andersen, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Fiona Chapman, Karin Roewer, Sandra Otte, Jeffrey Fisher, Matthew Stevenson   +10 more
doaj   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

Fixed-dose combination orally disintegrating tablets to treat cardiovascular disease: formulation, in vitro characterization and physiologically based pharmacokinetic modeling to assess bioavailability

Drug Design, Development and Therapy, 2017
Thomas J Dennison,1 Julian C Smith,2 Raj K Badhan,1 Afzal R Mohammed1 1Aston School of Pharmacy, Aston University, Birmingham, 2Viridian Pharma Ltd, Newport, UK Abstract: Cardiovascular disease (CVD) is the leading cause of death among men and women ...
Dennison TJ, Smith JC, Badhan RK, Mohammed AR   +3 more
doaj