Results 151 to 160 of about 15,765 (342)

Physiologically based pharmacokinetic models for systemic disposition of protein therapeutics in rabbits

Frontiers in Pharmacology
Physiologically based pharmacokinetic (PBPK) modelling is an important tool to predict drug disposition in the body. Rabbits play a pivotal role as a highly valued small animal model, particularly in the field of ocular therapeutics, where they serve as ...
Ravi Kumar Jairam, Maria Franz, Nina Hanke, Lars Kuepfer   +3 more
doaj   +1 more source

Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling [PDF]

, 2018
Nan‐Hung Hsieh, Brad Reisfeld, Frédéric Y. Bois, Weihsueh A. Chiu   +3 more
openalex   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling

Environment International
Understanding the binding between per- and polyfluoroalkyl substances (PFAS) and proteins is essential for elucidating their toxicokinetics and tissue distribution.
Xiarui Fan, Xiaomin Li, Tong Li, Bing Shao, Shan Niu, Wenhong Fan, Qi Wang, Lv Zhong, Xiangrui Wang, Ziwei Wang, Fujun Ma, Guomao Zheng, Hui Peng, Lili Chen, Zhaomin Dong   +14 more
doaj   +1 more source

Demystifying physiologically based pharmacokinetic modelling among non-modelers towards model-informed medicine use in under-served populations. [PDF]

Gates Open Res, 2023
Freriksen J, van der Heijden J, de Hoop-Sommen M, Johnson T, Yeo KR, Kerwash E, Cole S, Nooney J, Greupink R, Zhao P, de Wildt S.   +10 more
europepmc   +1 more source

Development of Physiologically Based Pharmacokinetic Model of Ethionamide in Pediatric Population by Application of Flavin-containing Monooxygenase 3 Maturation

, 2018
Nguyễn Thị Thu Phương, Parvez Md Masud, Min Jung Kim, Jung Ho Lee, Jong‐Lyul Ghim, Jae Gook Shin   +5 more
openalex   +2 more sources

Validation of Computational Approaches for Antiretroviral Dose Optimization (vol 60, pg 3838, 2016) [PDF]

, 2016
Dickinson, Laura, Owen, Andrew, Siccardi, Marco   +2 more
core   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Evaluation of the Drug–Drug Interaction Potential of the GlyT1 Inhibitor Iclepertin (BI 425809): A Physiologically Based Pharmacokinetic (PBPK) Modeling Approach [PDF]

Elin M. Matsson, Michael Desch, Valerie Nock, Nina Hanke   +3 more
openalex   +1 more source

Probabilistic human health risk assessment of perfluorooctane sulfonate (PFOS) by integrating in vitro, in vivo toxicity, and human epidemiological studies using a Bayesian-based dose-response assessment coupled with physiologically based pharmacokinetic (PBPK) modeling approach

, 2020
Wei‐Chun Chou, Zhoumeng Lin
openalex   +1 more source