Prediction of pediatric dose of tirzepatide from the reference adult dose using physiologically based pharmacokinetic modelling [PDF]
Frontiers in Pharmacology, 2023 Tirzepatide is an emerging hypoglycemic agent that has been increasing used in adults, yet its pharmacokinetic (PK) behavior and dosing regimen in pediatric population remain unclear.
Ruifang Guan +3 more
doaj +2 more sources
Lamivudine and Emtricitabine Dosing Proposal for Children with HIV and Chronic Kidney Disease, Supported by Physiologically Based Pharmacokinetic Modelling [PDF]
Pharmaceutics, 2023 Dose recommendations for lamivudine or emtricitabine in children with HIV and chronic kidney disease (CKD) are absent or not supported by clinical data.
Tom G. Jacobs +7 more
doaj +2 more sources
Physiologically-based pharmacokinetic modelling and dosing evaluation of gentamicin in neonates using PhysPK [PDF]
Frontiers in Pharmacology, 2022 Each year, infections caused around the 25% of neonatal deaths. Early empirical treatments help to reduce this mortality, although optimized dosing regimens are still lacking.
Hinojal Zazo +14 more
doaj +2 more sources
Physiologically Based Pharmacokinetic Modelling to Predict Pharmacokinetics of Enavogliflozin, a Sodium-Dependent Glucose Transporter 2 Inhibitor, in Humans [PDF]
Pharmaceutics, 2023 Enavogliflozin is a sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor approved for clinical use in South Korea. As SGLT2 inhibitors are a treatment option for patients with diabetes, enavogliflozin is expected to be prescribed in various ...
Min-Soo Kim +11 more
doaj +2 more sources
Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study [PDF]
Pharmaceutics, 2023 Imatinib is mainly metabolised by CYP3A4 and CYP2C8 and is extensively bound to α-acid glycoprotein (AAG). A physiologically based pharmacokinetic (PBPK) model for imatinib describing the CYP3A4-mediated autoinhibition during multiple dosing in ...
Karen Rowland Yeo +3 more
doaj +2 more sources
Data on ADME parameters of bisphenol A and its metabolites for use in physiologically based pharmacokinetic modelling [PDF]
Data in Brief, 2023 The paper presents the collection of physicochemical parameters of bisphenol A (BPA) and its sulfate (BPAS) and glucuronide (BPAG) conjugates, accompanied by data characterizing their absorption, distribution, metabolism and excretion (ADME) behavior ...
Barbara Wiśniowska +5 more
doaj +2 more sources
The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling [PDF]
Pharmaceutics, 2022 Background: pathophysiological changes such as low cardiac output (LCO) impact pharmacokinetics, but its extent may be different throughout pediatrics compared to adults. Physiologically based pharmacokinetic (PBPK) modelling enables further exploration.
Karel Allegaert +3 more
doaj +2 more sources
Evaluation of BCRP-Related DDIs Between Methotrexate and Cyclosporin A Using Physiologically Based Pharmacokinetic Modelling [PDF]
Drugs in R&DBackground and Objective This study provides a physiologically based pharmacokinetic (PBPK) model-based analysis of the potential drug–drug interaction (DDI) between cyclosporin A (CsA), a breast cancer resistance protein transporter (BCRP) inhibitor ...
Stephan Schaller +5 more
doaj +2 more sources
Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis [PDF]
Antibiotics, 2023 Linezolid is used off-label for treatment of central nervous system infections. However, its pharmacokinetics and target attainment in cranial cerebrospinal fluid (CSF) in tuberculous meningitis patients is unknown.
Carlijn H. C. Litjens +8 more
doaj +2 more sources
Mechanistic Insights into Cytokine Antagonist-Drug Interactions: A Physiologically Based Pharmacokinetic Modelling Approach with Tocilizumab as a Case Study [PDF]
PharmaceuticsBackground: Understanding interactions between cytokine antagonists and drugs is essential for effective medication management in inflammatory conditions.
Xian Pan +5 more
doaj +2 more sources