Results 11 to 20 of about 15,765 (342)

Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study [PDF]

Pharmaceutics, 2023
Imatinib is mainly metabolised by CYP3A4 and CYP2C8 and is extensively bound to α-acid glycoprotein (AAG). A physiologically based pharmacokinetic (PBPK) model for imatinib describing the CYP3A4-mediated autoinhibition during multiple dosing in ...
Karen Rowland Yeo, Oliver Hatley, Ben G. Small, Trevor N. Johnson   +3 more
doaj   +2 more sources

Data on ADME parameters of bisphenol A and its metabolites for use in physiologically based pharmacokinetic modelling [PDF]

Data in Brief, 2023
The paper presents the collection of physicochemical parameters of bisphenol A (BPA) and its sulfate (BPAS) and glucuronide (BPAG) conjugates, accompanied by data characterizing their absorption, distribution, metabolism and excretion (ADME) behavior ...
Barbara Wiśniowska, Susanne Linke, Sebastian Polak, Zofia Bielecka, Andreas Luch, Ralph Pirow   +5 more
doaj   +2 more sources

Evaluation of BCRP-Related DDIs Between Methotrexate and Cyclosporin A Using Physiologically Based Pharmacokinetic Modelling [PDF]

Drugs in R&D
Background and Objective This study provides a physiologically based pharmacokinetic (PBPK) model-based analysis of the potential drug–drug interaction (DDI) between cyclosporin A (CsA), a breast cancer resistance protein transporter (BCRP) inhibitor ...
Stephan Schaller, Ingrid Michon, Vanessa Baier, Frederico Severino Martins, Patrick Nolain, Amit Taneja   +5 more
doaj   +2 more sources

Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis [PDF]

Antibiotics, 2023
Linezolid is used off-label for treatment of central nervous system infections. However, its pharmacokinetics and target attainment in cranial cerebrospinal fluid (CSF) in tuberculous meningitis patients is unknown.
Carlijn H. C. Litjens, Laurens F. M. Verscheijden, Elin M. Svensson, Petra H. H. van den Broek, Hedwig van Hove, Jan B. Koenderink, Frans G. M. Russel, Rob E. Aarnoutse, Lindsey H. M. te Brake   +8 more
doaj   +2 more sources

Mechanistic Insights into Cytokine Antagonist-Drug Interactions: A Physiologically Based Pharmacokinetic Modelling Approach with Tocilizumab as a Case Study [PDF]

Pharmaceutics
Background: Understanding interactions between cytokine antagonists and drugs is essential for effective medication management in inflammatory conditions.
Xian Pan, Cong Liu, Felix Stader, Abdallah Derbalah, Masoud Jamei, Iain Gardner   +5 more
doaj   +2 more sources

Accuracy and precision analyses of single-time-point dosimetry utilising physiologically-based pharmacokinetic modelling and non-linear mixed-effects modelling [PDF]

EJNMMI Physics
Purpose The aim of this study was to investigate the accuracy and precision of single-time-point (STP) dosimetry using a physiologically-based pharmacokinetic (PBPK) model with non-linear mixed-effects modelling (NLMEM). Methods Biokinetic data of [111In]
Indra Budiansah, Deni Hardiansyah, Ade Riana, Supriyanto Ardjo Pawiro, Ambros J. Beer, Gerhard Glatting   +5 more
doaj   +2 more sources

Physiologically Based Pharmacokinetic Modelling of Cabozantinib to Simulate Enterohepatic Recirculation, Drug–Drug Interaction with Rifampin and Liver Impairment [PDF]

Pharmaceutics, 2021
Cabozantinib (CAB) is a receptor tyrosine kinase inhibitor approved for the treatment of several cancer types. Enterohepatic recirculation (EHC) of the substance is assumed but has not been further investigated yet.
Bettina Gerner, Oliver Scherf-Clavel
doaj   +2 more sources

Physiologically based pharmacokinetic modelling to predict artemether and lumefantrine exposure in neonates weighing less than 5 kg treated with artemether–lumefantrine to supplement the clinical data from the CALINA study [PDF]

Tropical Medicine and Health
Background Evidence-based recommendations for malaria treatment in patients weighing 
Helen Gu, Nada Abla, Vinay Kumar Venishetty, Birgit Schoeberl, Julia Zack, Heidi J. Einolf   +5 more
doaj   +2 more sources

Drug Dosing in Pediatrics: Possible Approaches

Вопросы современной педиатрии, 2023
Drug dosing remains one of the topical issues of modern pediatrics. Insufficient number of clinical studies, vulnerable patient populations (preterm newborns, patients with renal and/or hepatic insufficiency, obesity), and high risk of polypragmasy ...
Alexey S. Kolbin, Kseniya S. Radaeva
doaj   +1 more source

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]

, 2018
During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey, Bon, Cox, Darwich, Dorey, Duwal, Ette, Fink, Jamei, Jamei, Jeunesse, Li, Li, Lin, Maaland, Margolskee, Margolskee, Martinez, Martinez, Martinez, Mochel, Mochel, Mochel, Mochel, Mochel, Mould, Ogungbenro, Pade, Pade, Paulson, Pelligand, Rey, Rostami-Hodjegan, Sheiner, Silber, Sjögren, Toutain, Tsamandouras, T’jollyn, Willmann, Zhuang   +40 more
core   +7 more sources