Results 211 to 220 of about 15,765 (342)

Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption. [PDF]

Clin Pharmacokinet, 2022
Miller NA, Graves RH, Edwards CD, Amour A, Taylor E, Robb O, O'Brien B, Patel A, Harrell AW, Hessel EM.   +9 more
europepmc   +1 more source

PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELING: A TRANSFORMATIVE TOOL IN MODERN BIOPHARMACEUTICS

U. M. VAIDYA, I. AGARWAL, Shruti Bobade, Tillotma Gatkine Raut   +3 more
openalex   +1 more source

Physiologically Based Pharmacokinetic–Pharmacodynamic Modeling to the Rescue [PDF]

, 2014
Geoffrey T. Tucker
openalex   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Physiologically based pharmacokinetic modelling to predict potential drug-drug interactions of dersimelagon (MT-7117). [PDF]

Br J Clin Pharmacol
Ogasawara A, Kojima K, Murata Y, Shimizu H.   +3 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling in Pediatric Drug Development: A Clinician’s Request for a More Integrated Approach [PDF]

, 2012
Karel Allegaert, Anne Smits, Johannes N. van den Anker   +2 more
openalex   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment. [PDF]

Eur J Clin Pharmacol, 2022
Watanabe A, Ishizuka T, Yamada M, Igawa Y, Shimizu T, Ishizuka H.   +5 more
europepmc   +1 more source

Physiologically based pharmacokinetic modeling the reversible metabolism and tissue-specific partitioning of methylprednisolone and methylprednisone in rats

Ruihong Yu, William Jusko
openalex   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source