Physiologically Based Pharmacokinetic Modelling of Cabozantinib to Simulate Enterohepatic Recirculation, Drug–Drug Interaction with Rifampin and Liver Impairment [PDF]
Pharmaceutics, 2021 Cabozantinib (CAB) is a receptor tyrosine kinase inhibitor approved for the treatment of several cancer types. Enterohepatic recirculation (EHC) of the substance is assumed but has not been further investigated yet.
Bettina Gerner, Oliver Scherf-Clavel
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Accuracy and precision analyses of single-time-point dosimetry utilising physiologically-based pharmacokinetic modelling and non-linear mixed-effects modelling [PDF]
EJNMMI PhysicsPurpose The aim of this study was to investigate the accuracy and precision of single-time-point (STP) dosimetry using a physiologically-based pharmacokinetic (PBPK) model with non-linear mixed-effects modelling (NLMEM). Methods Biokinetic data of [111In]
Indra Budiansah +5 more
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Physiologically based pharmacokinetic modelling of atomoxetine with regard to CYP2D6 genotypes [PDF]
Sci Rep, 2018 Atomoxetine is a norepinephrine reuptake inhibitor indicated in the treatment of attention-deficit/hyperactivity disorder. It is primarily metabolized by CYP2D6 to its equipotent metabolite, 4-hydroxyatomoxetine, which promptly undergoes further ...
Se-Hyung Kim +6 more
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Physiologically based pharmacokinetic modelling to predict artemether and lumefantrine exposure in neonates weighing less than 5 kg treated with artemether–lumefantrine to supplement the clinical data from the CALINA study [PDF]
Tropical Medicine and HealthBackground Evidence-based recommendations for malaria treatment in patients weighing
Helen Gu +5 more
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Drug Dosing in Pediatrics: Possible Approaches
Вопросы современной педиатрии, 2023 Drug dosing remains one of the topical issues of modern pediatrics. Insufficient number of clinical studies, vulnerable patient populations (preterm newborns, patients with renal and/or hepatic insufficiency, obesity), and high risk of polypragmasy ...
Alexey S. Kolbin, Kseniya S. Radaeva
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Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]
, 2018 During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey +40 more
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Physiological modeling of isoprene dynamics in exhaled breath [PDF]
, 2003 Human breath contains a myriad of endogenous volatile organic compounds (VOCs) which are reflective of ongoing metabolic or physiological processes.
King, Julian +8 more
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Lost in modelling and simulation?
ADMET and DMPK, 2021 Over the past few decades, physiologically-based pharmacokinetic modelling (PBPK) has been anticipated to be a powerful tool to improve the productivity of drug discovery and development.
Kiyohiko Sugano
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Frontiers in Pharmacology, 2023 Sildenafil is a potent vasodilator and phosphodiesterase type five inhibitor, commercially known as Revatio® and approved for the treatment of pulmonary arterial hypertension.
Julia Macente +14 more
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Pharmaceutics, 2023 Physiologically based pharmacokinetic (PBPK) modelling is a bottom-up approach to predict pharmacokinetics in specific populations based on population-specific and medicine-specific data.
Martje Van Neste +6 more
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