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Physiologically based pharmacokinetic models for anticancer drugs
Cancer Chemotherapy and Pharmacology, 1979The rationale and history of the development of physiologically based pharmacokinetic models are briefly reviewed in this paper. The methods of model construction and the previous application of this type of model to anticancer drugs are discussed. Future research should be focused on the following areas: (1) interspecies scaling, (2) the effects of ...
H S, Chen, J F, Gross
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Physiologically Based Pharmacokinetic Models in Developmental Toxicology
Risk Analysis, 1994The kinetics of disposition of drugs and environmental chemicals will be altered as a result of the rapid and pronounced anatomic and physiologic changes that occur during pregnancy. These include changes in maternal intestinal motility, pulmonary tidal volume and minute volume, cardiac output, and renal function as well as in maternal tissue and fluid
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Structural Identifiability of Physiologically Based Pharmacokinetic Models
Journal of Pharmacokinetics and Pharmacodynamics, 2006When starting a project in drug kinetics it is necessary to test a priori whether there is sufficient information in the experimental input-output design to estimate unique values of internal rate constants. This is an important test if the pharmacokinetics of a drug are to be characterised in some way by the parameter values estimated from the ...
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Physiologically Based Pharmacokinetic (PBPK) Modeling in Children
Clinical Pharmacology & Therapeutics, 2012This review summarizes the present status of physiologically based pharmacokinetic (PBPK) modeling and simulation (M&S) and its application in support of pediatric drug research. We address the reasons that PBPK is suited to the current needs of pediatric drug development and pharmacotherapy in light of the evolution in pediatric PBPK methodologies and
J S, Barrett +3 more
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Lumping of Whole-Body Physiologically Based Pharmacokinetic Models
Journal of Pharmacokinetics and Biopharmaceutics, 1998Lumping is a common pragmatic approach aimed at the reduction of whole-body physiologically based pharmacokinetic (PBPK) model dimensionality and complexity. Incorrect lumping is equivalent to model misspecification with all the negative consequences to the subsequent model implementation.
Nestorov, Ivan A. +3 more
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Clinical Pharmacokinetics, 2013
Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the development pipeline in the pharmaceutical industry. More than 25 mAbs and derivatives have been approved for a variety of therapeutic applications.
Miroslav, Dostalek +4 more
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Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the development pipeline in the pharmaceutical industry. More than 25 mAbs and derivatives have been approved for a variety of therapeutic applications.
Miroslav, Dostalek +4 more
openaire +2 more sources