A Mechanistic, Model-Based Approach to Safety Assessment in Clinical Development [PDF]
, 2012 Peer ...
Becker, T +13 more
core +1 more source
Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits. [PDF]
PLoS ONE, 2018 The environmental fates of pharmaceuticals and the effects of crop protection products on non-target species are subjects that are undergoing intense review.
Panteleimon D Mavroudis +4 more
doaj +1 more source
A computational model of the hypothalamic - pituitary - gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone [PDF]
, 2011 © 2011 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Ankley, GT +12 more
core +7 more sources
A Physiologically Based Pharmacokinetic Model for Capreomycin [PDF]
Antimicrobial Agents and Chemotherapy, 2012 ABSTRACTThe emergence of multidrug-resistant tuberculosis (MDR-TB) has led to a renewed interest in the use of second-line antibiotic agents. Unfortunately, there are currently dearths of information, data, and computational models that can be used to help design rational regimens for administration of these drugs.
B, Reisfeld +5 more
openaire +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
A combined in vitro/in silico approach to identifying off-target receptor toxicity [PDF]
, 2018 Many xenobiotics can bind to off-target receptors and cause toxicity via the dysregulation of downstream transcription factors. Identification of subsequent off-target toxicity in these chemicals has often required extensive chemical testing in animal ...
Colley, H +9 more
core +4 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Frontiers in Pediatrics, 2021 Physiologically based pharmacokinetics (PBPK) modelling is widely used in medicine development and regulatory submissions. The lack of clinical pharmacokinetic data in pregnancy is widely acknowledged; therefore, one area of current interest is in the ...
Paola Coppola, Essam Kerwash, Susan Cole
doaj +1 more source
Sex differences in urinary levels of several biological indicators of exposure: a simulation study using a compartmental based toxicokinetic model [PDF]
, 2014 Toxicokinetic modeling is a useful tool to describe or predict the behavior of a chemical agent in the human or animal organism. A general model based on four compartments was developed in a previous study in order to quantify the effect of human ...
Tomicic, Catherine, Vernez, David
core +1 more source
An introduction to physiologically‐based pharmacokinetic models
Pediatric Anesthesia, 2016 SummaryPhysiologically‐based pharmacokinetic (PBPK) models represent drug kinetics in one or more ‘real’ organs (and hence require submodels of organs/tissues) and they describe ‘whole‐body’ kinetics by joining together submodels with drug transport by blood flow as dictated by anatomy.
Richard N. Upton +2 more
openaire +4 more sources