Results 71 to 80 of about 15,765 (342)

Potential drug-drug interaction of olverembatinib (HQP1351) using physiologically based pharmacokinetic models [PDF]

, 2022
Zhiheng Yu, Zihan Lei, Xueting Yao, Hengbang Wang, Miao Zhang, Zhe Hou, Yafen Li, Yangyu Zhao, Haiyan Li, Dongyang Liu, Yifan Zhai   +10 more
openalex   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Environment International, 2023
Human health risk assessment of chemicals is essential but often relies on time-consuming and animal and labor-extensive procedures. Here, we develop a population-based, quantitative in vitro to in vivo extrapolation (QIVIVE) approach which depended on ...
Chuanhai Li, Lidan Jiang, Donghui Zhang, Yuan Qi, Xinyi Wang, Yuan Jin, Xinya Liu, Yongfeng Lin, Jiao Luo, Lin Xu, Kunming Zhao, Dianke Yu   +11 more
doaj   +1 more source

Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance. [PDF]

, 2018
Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and conduct of clinical pharmacology research in children. During drug development, PKPD modeling and simulation should underpin rational trial design and facilitate extrapolation
A Cram, A Hooker, A Rao, AA Vinks, AH Thomson, AK Done, AM Johansson, AN Edginton, AN Edginton, AR Maharaj, AR Maharaj, B Green, B Quijano Ruiz, BJ Anderson, BJ Anderson, C Stockmann, CA Knibbe, CC Peck, CF Weiss, Charlotte I. S. Barker, CI Barker, CIS Barker, D Lin, DB Hawcutt, DJ Eleveld, E Germovsek, E Germovsek, E Germovsek, E Kimland, E Manolis, E Manolis, EI Ette, EI Ette, Eva Germovsek, F Rodieux, FG Benedict, G Langdon, G Nellis, GEP Box, GJ Robbie, GL Kearns, H Kimko, H Mulla, H Padari, H Shirkey, HG Eichler, HM Jones, HS Al-Sallami, I Adatia, I Bains, I Mahmood, I Mahmood, I Mahmood, IH Bartelink, J Alcorn, J Dunne, J Gillis, J Lerman, J Nyberg, J Nyberg, JA Roberts, JD Crawford, JE Sager, JF Standing, JF Standing, JF Standing, JK Roberts, JM Nicolas, Joseph F. Standing, JR Bellis, JS Barrett, JS Barrett, JS Barrett, JT Gilman, K Kipper, KD Wittmeier, KL Brouwer, L Aarons, L Cuzzolin, L Harnisch, L Harnisch, LE Kelly, LV Hampson, M Cella, M Cella, M Cella, M Danhof, M Jamei, M Kleiber, M Kleiber, M Minocha, M Neely, M Pfister, M Rowland, MA Montenegro, MA Turner, MA Turner, MA Turner, MA Turner, Mike Sharland, ML Christensen, MM Rhodin, MO Karlsson, MY Peeters, N Holford, N Kleiber, N Modi, NH Holford, P Espie, PA Valitalo, PD Joseph, PH Graaf van der, RE Kauffman, RF Cock De, RM Ward, RM Ward, RS Kadam, RW Jelliffe, S Conroy, S Duffull, S Feng, S Hennig, S Hennig, S Kanoh, S Leroux, SC McLeay, SE Tett, SG Wicha, SM MacLeod, SW Briggs, T Schechter, TA Leil, TA Leil, TH Nguyen, TN Johnson, TN Johnson, TN Johnson, TP Klassen, TS Samant, V Ramos-Martin, VH Tam, W Knebel, W Van’t Hoff, W Zhao, WA Silverman, Y Wang   +145 more
core   +2 more sources

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Physiologically Based Pharmacokinetic (PBPK) Models for Ethanol [PDF]

IEEE Transactions on Biomedical Engineering, 2008
Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for ...
Martin H, Plawecki, Jae-Joon, Han, Peter C, Doerschuk, Vijay A, Ramchandani, Sean J, O'Connor   +4 more
openaire   +2 more sources

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support the Clinical Management of Drug–Drug Interactions With Bictegravir [PDF]

, 2021
Felix Stader, Manuel Battegay, Catia Marzolini   +2 more
openalex   +1 more source

The SAFE-PEDRUG project : an opportunity for academia to close the gap [PDF]

, 2018
C
De Bruyne, Pauline, Vande Walle, Johan
core   +1 more source