Results 101 to 110 of about 3,860,015 (301)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Anthropometric Influence on Preschool Children’s Physical Fitness and Motor Skills: A Systematic Review

Journal of Functional Morphology and Kinesiology
Early childhood is a critical period for physical and motor development with implications for long-term health. This systematic review examined the relationship between anthropometric characteristics and measures of physical fitness and motor skills in ...
Markel Rico-González, Luca Paolo Ardigò, Ana P. Ramírez-Arroyo, Carlos D. Gómez-Carmona   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Effects of COVID-19 protective face masks and wearing durations on respiratory haemodynamic physiology and exhaled breath constituents

, 2022
Pritam Sukul, Julia Bartels, Patricia Fuchs, Phillip Trefz, Rasmus Remy, Leo Rührmund, Svend Kamysek, Jochen K. Schubert, Wolfram Miekisch   +8 more
openalex   +2 more sources

Spectral analysis of multiple time series [PDF]

, 1972
Application of spectral analysis for mathematically determining relationship of random vibrations in structures and concurrent events in electric circuits, physiology, economics, and seismograms is discussed.
Dubman, M. R.
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Towards industrial production of microalgae without temperature control: The effect of diel temperature fluctuations on microalgal physiology

, 2021
Robin Barten, Yovita Astuti Djohan, Wendy A. C. Evers, René H. Wijffels, María J. Barbosa   +4 more
openalex   +1 more source

Pupillometry: Psychology, Physiology, and Function

Journal of Cognition, 2018
Pupils respond to three distinct kinds of stimuli: they constrict in response to brightness (the pupil light response), constrict in response to near fixation (the pupil near response), and dilate in response to increases in arousal and mental effort ...
S. Mathôt
semanticscholar   +1 more source

Application of the International Centre of Insect Physiology and Ecology (ICIPE) for Inclusion into the CGIAR System [PDF]

, 1979
Documents concerning the application of the International Center for Insect Physiology and Ecology (ICIPE) for full CGIAR support and TAC's recommendation against offering such support.
International Centre of Insect Physiology and Ecology
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source