Results 111 to 120 of about 780,887 (251)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Promotion de la santé et prévention des maladies chroniques au CanadaIntroductionL’environnement bâti favorise l’activité physique en offrant des possibilités d’être actif dans sa vie quotidienne.
Stephanie A. Prince +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Le Jigsaw en Education Physique
, 2019 Rendre les élèves compétents en éducation physique (EP) est l’une des missions et préoccupations de l’enseignant. Diverses stratégies pédagogiques sont envisageables pour engager les élèves, les faire apprendre et les rendre plus compétents dans une ...
Lentillon-Kaestner, Vanessa +1 more
core
Quel avenir pour la physique ?
, 2016 Serge Haroche a reçu, avec David Wineland, le prix Nobel de physique en 2012 pour ses travaux sur « ...la manipulation de systèmes quantiques individuels » (voir l’article de Jean-Michel Raimond dans ce même numéro, p. 41).
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Femmes et Physique, la commission reprend du service
, 2012 La commission « Femmes et Physique » de la Société Française de Physique a pour objectif d’attirer, d’encourager et de promouvoir les femmes dans les métiers de la physique ...
Véronique Pierron-Bohnes
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