Results 101 to 110 of about 476,269 (286)
Olympiades de Physique France XXXI
La finale de la XXXIe édition du concours des Olympiades de Physique France, organisée à l’initiative de la Société Française de Physique et de l’Union des Professeurs de Physique et de Chimie, s’est déroulée à l’Université Paris Cité, sur le campus des ...
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Journal of Education, Health and Sport, 2015 Szary Mateusz, Napierała Marek, Pezala Małgorzata, Zukow Walery, Cieśłicka Mirosława, Muszkieta Radosław, Iermakov Sergii, Bartik Pavol, Eksterowicz Jerzy, Stępniak Robert, Karaskova Vlastimila.
Mateusz Szary +10 more
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Promotion de la santé et prévention des maladies chroniques au CanadaIntroductionLe but de cet article est d’explorer le lien entre l’activité physique à l’extérieur et la santé mentale, la satisfaction à l’égard de la vie, le bonheur et le stress chez les adolescents canadiens de 12 à 17 ans.
Taylor Bradbury +6 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Gesplitst in ... en: Journal de physique. 1: General physics, statistical physics, condensed matter, cross-disciplinary physics [ISSN 1155-4304]Gesplitst in ... en: Journal de physique.
Société française de physique biologique et médicale
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Femmes et Physique, la commission reprend du service
, 2012 La commission « Femmes et Physique » de la Société Française de Physique a pour objectif d’attirer, d’encourager et de promouvoir les femmes dans les métiers de la physique ...
Véronique Pierron-Bohnes
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source