Results 101 to 110 of about 780,887 (251)

Olympiades de Physique France, XXIV

, 2017
C’est à l’invitation de la délégation de Provence de la Société Française de Physique et de l’Union des Professeurs de Physique et de Chimie que la finale du concours des Olympiades de Physique France a été accueillie par Aix-Marseille Université, les 27

core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The effects of physical activity on social physique anxiety in college students—the mediating and moderating role of mental toughness and negative physical self

BMC Psychology
Purpose To examine the effects of physical activity on college students' social physique anxiety and the mediating and moderating roles of negative physical self and mental toughness in it, and to provide empirical evidence that physical activity ...
Yong Jiang, Xiaoyu Wang
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

La place du jeu en éducation physique [PDF]

Editorial du numéro 13 de la revue "Education physique en ...
Lentillon-Kaestner, Vanessa
core  

Physique nucléaire fondamentale

, 2016
La multiplication des appels à projets de physique appliquée, tant en France qu’en Europe, laisse présager une orientation de la recherche qui offrirait de moins en moins d’opportunités pour les investissements à long terme que nécessite la physique ...
Jérôme Margueron, Amel Korichi, Carlos Munoz Camacho, David Verney, Javier Castillo   +4 more
core   +1 more source

Niveaux d’activité physique des Canadiens sous l’angle de l’équité en matière de santé

Promotion de la santé et prévention des maladies chroniques au Canada
IntroductionCette étude a porté sur l’activité physique chez les jeunes (12 à 17 ans) et chez les adultes (18 ans et plus) vivant au Canada, en fonction de différentes catégories (genre, orientation sexuelle, groupes de population ...
Justin J. Lang, Sarah E. Turner, Natalie Doan, Iryna Demchenko, Stephanie A. Prince, Karen C. Roberts, Marisol T. Betancourt, Rachel Colley, Rabina Jahan, Ashley Amson, Jean-Philippe Chaput   +10 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source