Results 51 to 60 of about 1,254,085 (301)

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

Phytochemical analyses and pharmacological screening of Neem oil

South African Journal of Botany, 2019
Abstract An Italian certified Neem seed oil was characterized through the color analysis, the HPLC phenolic fingerprint and the preliminary evaluation of the cytotoxicity profile against the human macrophage (THP-1) cell line. Moreover, a wide screening of its enzyme inhibitory profile, antimicrobial activity towards Helicobacter pylori, several ...
Cesa, S., Sisto, F., Zengin, G., Scaccabarozzi, D., Kokolakis, A. K., Scaltrito, M. M., Grande, R., Locatelli, M., Cacciagrano, F., Angiolella, L., Campestre, C., Granese, A., Chimenti, P., Basilico, N.   +13 more
openaire   +5 more sources

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

ISOLATION AND IDENTIFICATION OF SECONDARY METABOLITES OF BLACK BETEL (Piper betle L. var Nigra)

Jurnal Kimia Riset, 2019
Piper betle L. var Nigra commonly known as black betel have a potential as drug raw materials. The leave of black betel  can be used to resist bleeding so as to accelerate the healing of wounds on the skin, sputum, other uses are for epistaxis, as well ...
Junairiah Junairiah, Ni’matuzahroh Ni’matuzahroh, Nabilah Istighfari Zuraidassanaaz, Lilis Sulistyorini   +3 more
doaj   +1 more source

Phytochemical screening of Capparis zeylanica

World Journal of Biology Pharmacy and Health Sciences
One important member of the Capparidaceae family is Capparis zeylanica Linn.plant in the Ayurvedic system of medicine, where it is used as a "Rasayan" drug. This plant has been reported to possess a range of pharmacological activities, including antioxidant, antipyretic, analgesic, anti-inflammatory, antimicrobial, and immunostimulant properties.
Vishwanath, Dongare Vishakha, Nandkumar, Padwal Prachi, Ashok, Bansode Kajal, Mubarak, Tamboli Layba   +3 more
openaire   +2 more sources

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Antihyperglycemic activity of Trichosanthes tricuspidata root extract

Bangladesh Journal of Pharmacology, 2013
To evaluate the anti-diabetic activity of ethanolic extract of Trichosanthes tricuspidata root in alloxan induced diabetic rats and to perform the phytochemical screening.
Srinivasan Kulandaivel, Pawan Bajpai, Thangavel Sivakumar   +2 more
doaj   +2 more sources

PHYTOCHEMICAL SCREENING OF VOLVARIELLA VOLVACEA (STRAW MUSHROOM) EXTRACT FROM ACEH’S LOCAL CULTIVATION

Jurnal Natural, 2018
. A research on analyzing the phytochemical content in Volvariella volvacea (straw mushroom) extract from a local cultivation in Aceh has been conducted. Straw mushroom is potentially a medicine ingredient.
Sadli .
doaj   +1 more source

Cyperus iria linn. Roots ethanol extract: its phytochemicals, cytotoxicity, and anti-inflammatory activity

Journal of Taibah University for Science, 2022
Inflammatory diseases are normally treated with non-steroidal anti-inflammatory drugs which may cause adverse effects if used for prolonged periods. Thus, there is a need to search for alternative anti-inflammatory medicine.
Peter Jan D. de Vera, Janeth C. Tayone, Ma. Cristina S. De Las Llagas   +2 more
doaj   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source