Results 191 to 200 of about 174,742 (304)

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Restoration of Immune Surveillance in Prostate Cancer Prevention by Sulforaphane in Hi‐Myc Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Oral administration of broccoli constituent sulforaphane (SFN) prevents prostate cancer development in preclinical mouse models. However, the mechanism(s) underlying prostate cancer prevention by SFN are not fully understood. In this study, we used a human relevant mouse model (Hi‐Myc mice) to demonstrate restoration of immune surveillance by ...
Krishna B. Singh, Eun‐Ryeong Hahm, Joshi J. Alumkal, Shivendra V. Singh   +3 more
wiley   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

The potential use of hydrogen in the extraction of phytochemicals from neglected and underutilized plant species for enhanced human nutrition. [PDF]

Front Nutr
Uçarer E, Hüdaverdi YA, Elnasanelkasim MA, Kavrut E, Alkan S, Bekbayev K, Toleugazykyzy A, Bolkenov B, Bekbayeva R, Samadun A, Alwazeer D.   +10 more
europepmc   +1 more source

Generalist‐pollinated Arabis alpina exhibits floral scent variation at multiple scales

Nordic Journal of Botany, EarlyView.
Plants that depend on animals for reproduction often use complex floral traits to attract pollinators. Floral scent is recognized as part of the pollinator attraction module and can be shaped by plant‐pollinator interactions. In recent decades, research has started to reveal the dynamic properties of floral scent, identifying patterns of spatial and ...
Hanna Thosteman, Katherine Eisen, Clara McNaughton Montgomery, Xuefei Cheng, Loretta Pace, Magne Friberg   +5 more
wiley   +1 more source

Dual-mechanism of phytochemicals in cancer therapy: synergistic anti-angiogenic potency in cancer and proangiogenic impact against chemotherapy-induced cytotoxicity in vital organs. [PDF]

Front Pharmacol
Elsayed Abouzed DE, Bayoumy NMK, Hagar H, Rabea SM, Hashem H, Khalifa HO.   +5 more
europepmc   +1 more source

Meyna grisea (King & Gamble) Robyns and Meyna peltata Robyns (Rubiaceae: Vanguerieae) – a new record of two ethnobotanically significant fruit trees from Manipur, India

Nordic Journal of Botany, EarlyView.
Meyna grisea and M. peltata, two new records from Imphal Valley, Manipur, India, characterised by a capitate stigma with 4–5 divergent, spreading lobes on a globose base, and a prominent peltate stigma, respectively, are described and illustrated here. Photographs, key to the species, along with their coordinates and diagnostic characters in comparison
Pallavi B. Dhal, Anishya, Sachchidanand Tripathi, Rajkumari Sanayaima Devi   +3 more
wiley   +1 more source

Correction to 'Counteracting Skin Aging In Vitro by Phytochemicals'. [PDF]

J Cell Mol Med
europepmc   +1 more source

Inhibitory effect of the methanol extract of Clerodendrum volubile Linn. on carbon tetrachloride-induced early hepatic fibrogenesis: in silico and in vivo study. [PDF]

Sci Rep
Oyeyemi IT, Asowata-Ayodele AM, Adetula AO, Sulaiman KA, Omape DE, Fageyinbo MS.   +5 more
europepmc   +1 more source