Results 61 to 70 of about 7,375 (146)

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

open access: yesFood Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima   +15 more
wiley   +1 more source

Chemoprevention of LA7-Induced Mammary Tumor Growth by SM6Met, a Well-Characterized Cyclopia Extract

open access: yesFrontiers in Pharmacology, 2018
Breast cancer (BC) is the leading cause of cancer-related deaths in women. Chemoprevention of BC by using plant extracts is gaining attention. SM6Met, a well-characterized extract of Cyclopia subternata with reported selective estrogen receptor subtype ...
Omolola R. Oyenihi   +7 more
doaj   +1 more source

Phytoestrogens: Food or Drug? [PDF]

open access: yes, 2006
Within the past several years, the relation between diet and health has been accepted by the mainstream nutrition community and in this connection interest in the physiological role of bioactive compounds present in plants has dramatically increased over the last decade.The phytoestrogens are bioactive molecules present as nutritional constituents of ...
BACCIOTTINI, LUCIA   +5 more
openaire   +3 more sources

A molecular docking study of phytoestrogenic compounds from Hypericum perforatum L. and Anethum graveolens L. with two isoforms of estrogen receptor

open access: yesArmaghane Danesh Bimonthly Journal, 2021
Background and aim: Estrogens play a key role in the growth, development and maintenance of a wide range of tissues. Physiological responses to estrogen in specific tissues are mediated by at least two isoforms of the estrogen receptor alpha (ERα) and ...
Mahboubeh Mansourian
doaj  

The effects of hydro-alcoholic extract of Vitex agnus-castus L. on the growth indices and survival rate in Zebrafish (Danio rerio)

open access: yesیافته‌های نوین در علوم زیستی, 2017
In the research project performed, the effects of different levels of hydro-alcoholic extract Vitex agnus-castus were investigated as nutritional supplement on growth parameters of Danio rerio for 4 months.
Tayebeh Enayat Gholampour   +3 more
doaj  

Phylogeny, ethnomedicinal use and the distribution of phytoestrogens in the Fabaceae

open access: yesFrontiers in Pharmacology
IntroductionPhytoestrogens, with estrogenic activity, are commonly found across the Fabaceae family. Here we develop methods that use phylogeny and ethnomedicinal information in order to identify candidate species for novel phytoestrogens.MethodWe ...
Kongkidakorn Thaweepanyaporn   +3 more
doaj   +1 more source

Effects of genistein and genistin on in vitro maturation of pig oocytes

open access: yesCzech Journal of Animal Science, 2008
The objective of the study was to verify the hypothesis that GEN (genistein - phytoestrogen and an inhibitor of tyrosine protein kinase - TPK) effects on pig oocyte maturation and cumular cell expansion under in vitro conditions are connected with its ...
Z. Vodková   +4 more
doaj   +1 more source

Differential effects of genistein and 8-prenylgenistein on reproductive tissues in immature female mice

open access: yesPharmaceutical Biology, 2019
Context: We identified an active prenylated derivative of genistein, 8-prenylgenistein (8PG) from Erythrina variegata L. (Leguminosae) and found that 8PG increased osteoprotective effects of genistein in oestrogen-deficient mice.
Xiao-Li Li   +5 more
doaj   +1 more source

Genistein Effect on Sex Hormones, Sperm Count and Sperm Viability in Male Rats

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2011
BACKGROUND AND OBJECTIVE: Genistein is a soya phytoestrogen having estrogenic effects. Phytoestrogen has been introduced as one of the elements of unproductively in some animals, but previous studies on genistein role in male reproductive system have ...
R Ghorbani   +3 more
doaj  

Phytoestrogens in osteoporosis

open access: yesWiadomości Lekarskie
This article explores the role of phytoestrogens in the prevention and treatment of osteoporosis, focusing on soy isoflavones, red clover, and other plants such as Epimedium, hops, fennel, and prunes. It reviews clinical trials examining the effects of these phytoestrogens on bone mineral density (BMD), bone turnover markers, and osteoporotic fracture ...
Mateusz Kaczmarski   +9 more
openaire   +3 more sources

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