Results 71 to 80 of about 25,442,440 (283)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Enhanced antitumoral activity of the academic CAR-T ARI0002h against normal and low BCMA-expressing myeloma cells after incorporating a transmembrane CD28 domain

Journal for ImmunoTherapy of Cancer
Background B-cell maturation antigen (BCMA) is the main target for chimeric antigen receptor (CAR)-T cells in multiple myeloma (MM), demonstrating promising outcomes.
Lorena Pérez-Amill, Alvaro Urbano-Ispizua, Beatriz Martín-Antonio, Aina Oliver-Caldes, David F Moreno, Luis Gerardo Rodríguez-Lobato, Carlos Fernández de Larrea, Oriol Cardus, Joan Mañé Pujol, Anna de Daniel, Theo Gremen M Oliveira, Anthony M Battram, Sergi V Salsench, Helena Llobregat, Judit Carpio Mármol, Daniel Munárriz   +15 more
doaj   +1 more source

Pi-Pi interaction parameters for each compound and STING residues.

, 2019
Pi-Pi interaction parameters for each compound and STING residues.
Xinhui Wang (126681), Weihang Li (6729335), Yang Bai (198601), Sheng Zhong (88247), Bo Wu (16141), Shanshan Jiang (382941), Jiaxin Ren (6729341), Rihua Jin (6729344), Yingjing Zhao (6729338), Hui Li (32376)   +9 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Drug-Loaded Red Blood Cell–Derived Carriers for Targeted Delivery to Accelerate Tissue Regeneration

Pharmaceutics
Background/Objectives: Diabetic foot ulcers are characterized by persistent inflammation, impaired angiogenesis, and delayed tissue regeneration.
Kulzhan Berikkhanova, Yernur Zakirov, Askhat Zhilkaidarov, Nurgul Daniyeva, Erlan Taigulov, Saken Kozhakhmetov, Ardak Omarbekov, Beibarys Amankeldin, Gulyash Tanysheva, Nurzhan Berikkhanov, Yessenkhan Sultan, Zhanas Baimagambet, Isah Inuwa, Saule Aliyeva   +13 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Midiendo Pi

, 2013
Educação Infantil::Natureza e sociedadeGuia de experimento que permite demonstrar como encontrar e calcular o valor de PI de objetos ...
Varela, Antonio
core   +3 more sources

Early Pupil Abnormality Frequency Predicts Poor Outcomes and Enhances International Mission for Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) Model Prognostication in Traumatic Brain Injury

Critical Care Explorations
IMPORTANCE:. In patients with traumatic brain injury (TBI), baseline pupillary assessment is routine; however, the occurrence rate and clinical significance of pupil abnormalities over the early course of hospitalization remain poorly characterized ...
Divya Veerapaneni, MD, Naveen Arunachalam Sakthiyendran, BS, Yili Du, MS, Leigh Ann Mallinger, BS, Allyson Reinert, BS, So Yeon Kim, MPH, Chuong Nguyen, BS, Ali Daneshmand, MD, MPH, Mohamad Abdalkader, MD, Shariq Mohammed, PhD, Josée Dupuis, PhD, Kevin N. Sheth, MD, Emily J. Gilmore, MD, David Greer, MD, MA, Charlene J. Ong, MD, MPHS   +14 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source