Results 131 to 140 of about 442,345 (289)

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

PI-RADS upgrading as the strongest predictor for the presence of clinically significant prostate cancer in patients with initial PI-RADS-3 lesions

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Unclear lesions on multiparametric magnetic resonance tomography (mpMRI) are challenging for the ...
Thomas, Christian, Platzek, Ivan, Baunacke, Martin, Kwe, Jeremy, Boehm, Katharina, Borkowetz, Angelika   +5 more
core   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Structured report of prostate MRI based on Prostate Imaging Reporting and Data System Version 2

肿瘤影像学, 2016
The Prostate Imaging Reporting and Data System Version 2 (PI-RADS V2) is a system aimed at the diagnosis of clinically significant cancer in prostate by using multiparametric magnetic resonance imaging (mpMRI).
QIN Xiubo, WANG Rui, GAO Ge, WANG He, GUO Xiaochao, ZHANG Xiaodong, CAO Min, ZHANG Suisui, YUE Xin, WANG Xiaoying   +9 more
doaj  

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Deep-learning computer-aided detection and classification of prostate lesions on biparametric MRI: comparison with expert readers

Insights into Imaging
Objective To assess the performance of a deep learning-based computer-aided detection (DL-CAD) algorithm for prostate lesion detection and classification on biparametric (bp)MRI.
Deepak Jain, Francisco Restrepo, Kazuya Yasokawa, Efe Ozkaya, Mickael Tordjman, Marc Berns, Alon Slutzky, Julian Franko, Octavia Bane, Heinrich von Busch, Robert Grimm, Ashutosh K. Tewari, Sara Lewis, Bachir Taouli   +13 more
doaj   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

Diagnostic Value of FPSAD and PI-RADS v2.1 for Clinically Significant Prostate Cancer in Patients with tPSA Levels of 4-10 ng/mL

Cancer Management and Research
Wei Guo, Ping Tan, Yan He, Xinyu Yi Department of Urology, Xiangtan Central Hospital, Xiangtan, Hunan, People’s Republic of ChinaCorrespondence: Xinyu Yi, Email 1225020697@qq.comObjective:  To evaluate the incremental diagnostic value of combining free ...
Guo W, Tan P, He Y, Yi X
doaj  

Ion‐Reconfigurable “N”‐Shaped Antiambipolar Behavior in Organic Electrochemical Transistors

Advanced Materials, EarlyView.
A unique N‐shaped negative differential transconductance (NDT) characteristics is demonstrated in single‐polymer organic electrochemical transistors through a sequential doping–redox–doping process driven by iodide ions. This redox‐driven mechanism enables low‐voltage, ion‐controlled reconfigurability and tunable current modulation, allowing seamless ...
Debdatta Panigrahi, Daniele Zucchelli, Zeinab Hamid, Christina Kousseff, Arup Sarkar, Aristea Pavlou, Zhitian Ling, Somayeh Kashani, Iain McCulloch, Paul W. M. Blom, Fabrizio Torricelli, Paschalis Gkoupidenis   +11 more
wiley   +1 more source

Limits to the Hall Effect and Other Nonreciprocal Effects in Three‐Dimensional Metamaterials

Advanced Materials, EarlyView.
Comprehensive and fundamental bounds on nonreciprocal effects in three‐dimensional metamaterials are derived. They reveal that the effective Hall mobility cannot exceed the largest constituent mobility, that, under certain conditions, the Verdet constant cannot be enhanced, and that, for constituents with Hall coefficients of the same sign, the largest
Christian Kern, Graeme W. Milton
wiley   +1 more source