Results 121 to 130 of about 2,909,495 (269)
Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig +10 morewiley +1 more sourcePI Debriefing
, 1972 The PI Debriefing for the Skylab Medical Experiments Altitude Test ...core Real-time PCR detection of PI*S and PI*Z alleles of SERPINA1 gene using SYBR green
GeneAlpha-1 antitrypsin deficiency is an underdiagnosed genetic condition that predisposes to pulmonary complications and is mainly caused by rs28929474 (PI*Z allele) and rs17580 (PI*S allele) mutations in the SERPINA1 gene.Development of a homogeneous genotyping test for detection of PI*S and PI*Z alleles based on the principles of allele-specific PCR and González Carracedo, Mario Andrés, Ramos Díaz, Ruth, Escuela Escobar, Ainhoa, Díaz Usera, Ana, Hernández Pérez, José María, Pérez Pérez, José Antonio +5 moreopenaire +3 more sourcesCell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis +10 morewiley +1 more sourceSearch for the Z(1)(4050)(+) and Z(2)(4250)(+) states in (B)over-bar(0) -> chi K-c1(-)pi(+) and B+ -> chi K-c1(S)0 pi(+)
, 2012 We search for the Z(1)(4050)(+) and Z(2)(4250)(+) states, reported by the Belle Collaboration, decaying to chi(c1)pi(+) in the decays (B) over bar (0) -> chi K-c1(-)pi(+) and B+ -> chi K-c1(S)0 pi(+) where chi(c1) -> J/psi gamma.Bailey D, Wilson FF, SANTORO, Valentina, Hutchcroft DE, de Monchenault GH, Uwer U., Toki WH, Akar S., Innes W. R., Piccolo M., Solodov EP, Davis C. L., Sinev NB, Munerato M., Robertson S. H., Fioravanti E., Peruzzi I. M., Spaan B., Malaescu B, Kobel M. J., Pacetti S, Coleman J. P., Piccolo M, Ocariz J, Neri N., Sokoloff M. D., Prepost R., Rotondo M, Snyder A, Nauenberg U, Kravchenko E. A., Benitez J. F., Blinov V. E., Gershon T. J., Hartmann T., Harrison PF, Pennington M. R., Lewczuk M. J., Andreassen R, Lee CL, Derkach D, Vitug G. M., Feltresi E., Nguyen X., Nagel M., Young C. C., Poireau V, Lo Vetere M, Wulsin HW, McKenna JA, Nicolaci M., Gaspero M., Gioi LL, Puccio EMT, Ocariz J., Cowan G, Skovpen YI, Wilson JR, Salnikov A. A., Fulsom BG, Morii M., Bailey D., de Sangro R, Pulliam T, Clark P. J., Chen C, Dubois Felsmann GP, Saeed M. A., Biassoni P., Sciolla G, Smith AJS, Nelson S, Cochran J, Gagliardi N, Lacker HM, Schubert KR, Patteri P., Giorgi MA, Manoni E., Schumm BA, Bingham I, Fry JR, Grosdidier G., Perez A, Lou X. C., Miyashita T. S., Stugu B., Waldi R, Kobel MJ, Bianchi F, Adametz A, Alam MS, Sun S., PAPPAGALLO, MARCO IGNAZIO, Stroili R., Marks J, Behn E, Lacker H. M., Chauveau J, PALANO, Antimo, Contri R, Edwards A. J., Echenard B., Luppi E., CIBINETTO, Gianluigi, Gaspero M, Flood K. T., Di Lodovico F., Bard D. J., Sobie RJ, Hong TM, Briand H., Ziegler V., Baldini Ferroli R., Atmacan H., Leith D. W. G. S., Davis CL, Behera PK, Schram M, Mandelkern M, Bevan A. J., Wilson J. R., Puccio E. M. T., Leith DWGS, Milanes DA, Purohit MV, King GJ, Arnaud N, Roudeau P, Muller DR, Vasseur G., Patrignani C., Behera P. K., Roodman A., Schroeder T, Alwyn K. E., GIORGI, MARCELLO, Fry J. R., Rotondo M., Alam M. S., Wray BC, CARPINELLI, Massimo, Kolomensky YG, Martinez-Vidal F, Cremaldi L, Lutz AM, Cowan R, West CA, Mallik U, Sevilla MF, Summers DJ, Kirkby D, Eckmann R, Hitlin D. G., White RM, Touramanis C, Lopes Pegna D, Sitt S, Va'vra J., Rosenberg EI, Guido E., Patel P. M., Lindquist B., Wormser G., Stracka S, Wilson F. F., Rakitin AY, Bevan AJ, Olaiya EO, CALDERINI, GIOVANNI, Simi G, Schalk T., Sinev N. B., Biasini M, Guo Z. J., Ford W. T., Roney J. M., Wagner SR, Bloom PC, Lafferty G. D., Bartoldus R., Jessop C. P., Long O., Voss C, Echenard B, Brown D. N., Graham M. T., Rakitin A. Y., Wormser G, Bettoni D, Di Lodovico F, Lund P, Chavez C. A., Leruste P, Vuosalo C. O., Ruland A. M., Khan A, Hutchcroft D. E., Choi H. H. F., Martinez A. J., Wulsin H. W., Verderi M., Soffer A., Piredda G., Kim H., Buzykaev A. R., Passaggio S, Bloom P. C., Su D., Lutz A. M., Luppi E, GARZIA, Isabella, Poireau V., Eigen G, Ayad R, Todyshev K. Y.u., Todyshev KY, Bettoni D., Godang R., Zallo A., Gioi L. Li, Druzhinin VP, Ebert M, Guttman N., Band H. R., Milanes D. A., Roudeau P., Lund P., Rizzo G, Clark PJ, Wu SL, Martinez Vidal F, Denig A. G., Latham TE, Sekula S. J., Negrini M., Ziegler V, Hearty C, Gritsan A. V., Smith A. J. S., Richman J. D., Golubev VB, Marchiori G., Schwierz R, Roney JM, Hafner A, Wagner A. P., Martinelli M, Bernard D, Cibinetto G, Soffer A, Garzia I., Oyanguren A, Luth V, Sciacca C, Calabrese R, Prell S, Lange DJ, Ford WT, Leruste P.h., Carpinelli M., Oyanguren A., Rossi A., Banerjee Sw, Lou XC, Stugu B, Edwards AJ, Sciolla G., Angelini C., Seiden A, Hast C, Santoro V., Roberts DA, Gorodeisky R., Vitale L., Stroili R, Hamon O, West C. A., Ernst JA, Prasad V., Latham T. E., Sigamani M, Pappagallo M, Payne D. J., Tisserand V., Gary JW, Bartoldus R, Yarritu A. K., Jackson G, Onuchin AP, Posocco M, Grauges E, Raven G, King G. J., Miyashita TS, Biassoni P, Guttman N, Aston D., Schindler R. H., Pappagallo M., Prepost R, Walsh JJ, Izen JM, Eigen G., Hong T. M., Sekula SJ, Strom D, Dasu S., Angelini C, Grünberg O, Bingham I., Kroseberg J, Meadows BT, Wittgen M., Gritsan AV, Onorato G, PAOLONI, EUGENIO, Bellis M, Seiden A., Morandin M., Barlow RJ, Torrence E, Weaver M, Schilling CJ, STRACKA, SIMONE, O'Grady C. P., Cartaro C., Gary J. W., Frey R, Lockman WS, Kocian M. L., Dallapiccola C, Hamon O., Sitt S., Pegna D. Lopes, Tasneem N., Porter FC, Baldini Ferroli R, Smith JG, Pegna DL, Cowan G., Coleman JP, Kroeger R, Prell S., Gamba D., Andreassen R., Nauenberg U., Forti F, Paoloni E., MacFarlane D. B., Cochran J., Gradl W., Lindemann D, Solodov E. P., Fioravanti E, Oberhof B., Snyder A., Contri R., Eisner AM, RIZZO, GIULIANA, Va’vra J, Pan Y., Wittgen M, Biasini M., Bondioli M., Ebert M., Honscheid K, Toki W. H., Jawahery A, Raven G., Nagel M, Sun L, Cremaldi L., Cenci R, Pacetti S., Voss C., MacFarlane DB, Cheng CH, Tico JG, McKenna J. A., Kass R., Suzuki K., Atmacan H, Adye T, Chavez CA, Schwiening J., Ahmed H., Sullivan M. K., Schwierz R., Wang W. F., Tasneem N, Bozzi C., Bernlochner F. U., Lafferty GD, Li S., ANGELINI, CARLO, Lees J. P., Harrison P. F., Dorfan J., Playfer S, LoSecco J. M., Ferrarotto F., Casarosa G., Yèche C, Ben Haim E, Luitz S., Wang WF, Bondioli M, Khan A., Cartaro C, Knoepfel K. J., Meyer W. T., Bünger C, Burchat PR, Stocchi A., Walsh J. J., Bellis M., Marsiske H., Patrignani C, Campagnari C., Peruzzi IM, Bettarini S., Hast C., Neri N, Monorchio D., Chauveau J., Yushkov AN, Verderi M, de Monchenault G. Hamel, Lopez March N., Wray B. C., Cowan R., Muller D. R., Patel PM, Grosdidier G, Sevilla M. Franco, Bernlochner FU, Stoker D. P., Torrence E., Dallapiccola C., Cervelli A, Onuchin A. P., Bianchi F., Nicolaci M, Stracka S., Sacco R., Telnov AV, Vitale L, Kelsey M. H., LoSecco JM, Olsen J, Piredda G, Eckmann R., Fritsch M., Roodman A, Choi HHF, Wagner AP, Serednyakov SI, Kass R, Bonneaud GR, Lankford AJ, Schilling C. J., Young CC, Flood KT, Simonetto F, Peimer D. R., Calderini G, Simard M, Hitlin DG, Marchiori G, Koch H, Dujmic D., Yeche C.h., White R. M., Sobie R. J., Pan B., Mandelkern M., Mattison T. S., Lueck T., Monge MR, Waldi R., LUSIANI, Alberto, Uwer U, Robutti E, Martinez AJ, Gruenberg O., Emery S., Kroeger R., Lindemann D., Blinov VE, Cibinetto G., Sigamani M., Le Diberder F., Mallik U., Gabathuler E., Purohit M. V., Jackson G., Olaiya E. O., Kovalskyi D, Vetere ML, Brau J, Ratcliff B. N., Kirkby D., Frey R., Banerjee S.w., BATIGNANI, GIOVANNI, Anulli F, Luitz S, Bernard D., Giorgi M. A., Thompson J. M., Manoni E, Va'vra J, Zallo A, Guido E, Zain S. B., Lanceri L, Li Gioi L, Liu F., Simonetto F., Liu F, Richman JD, Kowalewski R., Paoloni E, Ben-Haim E, Bozzi C, Hearty C., Ahmed H, Taras P., Smith J. G., Simi G., Kim P., Mazzoni M. A., Morii M, Monge M. R., Buzykaev AR, Luth V., Dauncey PD, Martinelli M., Doll D. A., Huard Z, Perl M, Prencipe E., Neal H, Sciacca C., Kowalewski R, Guo ZJ, Randle Conde A, Mazzoni MA, Brau J., Strom D., Asgeirsson DJ, Sonnek P, Nugent I. M., Franco Sevilla M, Wisniewski WJ, Mattison TS, Vasseur G, Nelson S., Weaver M., Patteri P, Schram M., Ahmed S., Brown DN, Ben Haim E., Buenger C., Derkach D., Hamilton B., Vitug GM, Bonneaud G. R., Park W., Schröder H, Gabathuler E, Spanier S. M., Lees JP, Bhuyan B, Neal H., Calabrese R., FORTI, FRANCESCO, Kerth LT, Robertson SH, Graham MT, Rosenberg E. I., Grauges E., Hafner A., Bomben M., Feltresi E, Honscheid K., Carpinelli M, Dasu S, Wagner S. R., Pulliam T., Benitez JF, Chen X. R., Band HR, Gabareen AM, Convery MR, Lindquist B, Ferroni F., Margoni M., Gershon TJ, Kovalskyi D., Adametz A., de Sangro R., Ferrarotto F, Field R. C., Serednyakov S. I., Lueck T, Rizzo G., Vetere M. Lo, Grenier P., Nugent IM, Palano A., Kravchenko EA, Albert J., Peimer DR, Pan Y, Sokoloff MD, Doll DA, Snoek HL, Perez A., Ferroni F, Koch H., Su D, Schwitters RF, Ruland AM, Baldini-Ferroli R, Garra Tico J., Schune M. H., Knoepfel KJ, Piemontese L., Cervelli A., Gorodeisky R, Rossi A, Palombo F, Wright D. M., Lindsay C., Touramanis C., Palombo F., Snoek H. L., Le Diberder F, Monorchio D, Olsen J., FIORAVANTI, Elisa, Onorato G., De Nardo G, Lynch G, Lusiani A., Spanier SM, Cheng C. H., Dorfan J, Calderini G., Lu C., Davier M., Wisniewski W. J., Stocchi A, Fritsch M, Dunwoodie W., Payne DJ, Salnikov AA, Jawahery A., Gamba D, Santoro V, Oberhof B, Batignani G., Simard M., Dujmic D, LUPPI, Eleonora, Porter F. C., Adye T., Finocchiaro G, Lynch H. L., Stoker DP, Vuosalo CO, Golubev V. B., Rubin AE, Meadows B. T., Faccini R., Palano A, Negrini M, Tisserand V, Posocco M., Schroeder T., Randle-Conde A, Lewis P, Lange D. J., Briand H, Robutti E., Ernst J. A., Hamel de Monchenault G, Hamilton B, Bettarini S, Piemontese L, Skovpen Y.u. I., Behn E., Lusiani A, Cavoto G, Dauncey P. D., Marks J., Chen C., Kolomensky Y.u. G., Denig AG, Anulli F., Yarritu AK, Schalk T, Grenier P, Leddig T., Lankford A. J., Ofte I., Hartmann T, Passaggio S., Fulsom B. G., Asgeirsson D. J., Yushkov A. N., Rama M, Schune MH, Sonnek P., Malaescu B., Hamano K., Aston D, Playfer S., Schindler RH, Perl M., Gaz A, Albert J, CALABRESE, Roberto, Innes WR, Lockman W. S., Alwyn KE, Izen J. M., Emery S, Telnov A. V., Dunwoodie W, Schroeder H., Schumm B. A., Sacco R, Pelliccioni M., Garzia I, De Nardo G., Dubois-Felsmann GP, Bomben M, Leddig T, Arnaud N., Calcaterra A, Druzhinin V. P., Sullivan MK, Gagliardi N., Wu SLam TE, Kim P, Margoni M, Field RC, Martinez Vidal F., Roberts D. A., Prencipe E, BETTARINI, STEFANO, Randle Conde A., Bard DJ, Ritchie J. L., Taras P, Lanceri L., Gabareen A. M., Jessop CP, BOZZI, Concezio, Cavoto G., Kroseberg J., Cenci R., Ongmongkolkul P, Lee C. L., Prasad V, Campagnari C, Garra Tico J, Kerth L. T., Faccini R, Summers D. J., Akar S, Sun L., Ayad R., Casarosa G, Gradl W, Lynch G., BETTONI, Diego, Kocian ML, Lu C, Barlow R. J., Forti F., Kelsey MH, Rubin A. E., Burchat P. R., Schwitters R. F., Wright D. H., Lewczuk MJ, Meyer WT, Wright DM, Wu S. L., Godang R, Long O, Park W, Morandin M, Ratcliff BN, Eisner A. M., Gaz A., Dubois Felsmann G. P., Spaan B, Munerato M, Lynch HL, Banerjee S, Batignani G, Nguyen X, Huard Z., Convery M. R., Finocchiaro G., Calcaterra A., Lewis P., Bhuyan B., Rama M., Ritchie JL, Davier M, Schubert K. R., Wright DH, Ongmongkolkul P. +819 morecore +1 more sourceHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more sourceProteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi +10 morewiley +1 more sourceA Foreign Function Interface Generator for occam-pi [PDF]
, 2005 . occam-pi is a programming language based on the CSP process algebra and the pi-calculus, and has a powerful syntax for expressing concurrency. occam-pi does not however, come with interfaces to a broad range of standard libraries (such as those used ...Jacobsen, Christian L., Christan L. Jacobsen, Damian J. Dimmich, Dimmich, Damian J. +3 morecore
