Results 131 to 140 of about 2,909,495 (269)

Increased exacerbations and hospitalizations among PI*MZ compared to PI*MM individuals: an electronic health record analysis

Respiratory Research
Background The best described endotype of COPD is alpha-1 antitrypsin (AAT) deficiency, due to a genetic abnormality in the SERPINA1 gene. Common deficient PI variants are the Z and S variants.
Vickram Tejwani, Yifan Wang, Lauren Munoz Tremblay, Elizabeth Azzato, Arianne K. Baldomero, Christine Wendt, Amy Attaway, Russell Bowler, Umur Hatipoglu, Rebecca Hutton, Charlie Strange, Xiaofeng Wang, Victor E. Ortega, Joe Zein, James K. Stoller   +14 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Time course of glucose consumption and ethanol production for free Z. mobilis and PI-Z. mobilis.

, 2013
Fermentation of free Z. mobilis was carried out at 35°C and pH 5, with an initial glucose concentration of 100 g/l. Fermentation of PI-Z. mobilis was carried out at 30°C and pH 7, with an initial glucose concentration of 100 g/l. Glucose concentration of
Zijian Zhao (484183), Jiayin Liu (213071), Zhengqiang Li (484185), Haoran Xu (484184), Xuedun Niu (134398), Yang Li (7082), Zhi Wang (193655), Li Jiang (120930)   +7 more
core   +1 more source

Alpha1-antitrypsin deficiency in Greece: Focus on rare variants

Pulmonology
Purpose A1Antitrypsin deficiency (AATD) pathogenic mutations are expanding beyond the PI*Z and PI*S to a multitude of rare variants.Aim to investigate genotype and clinical profile of Greeks with AATD.Methods Symptomatic adult-patients with early ...
S.A. Papiris, M. Veith, A.I. Papaioannou, V. Apollonatou, I. Ferrarotti, S. Ottaviani, A. Tzouvelekis, V. Tzilas, N. Rovina, G. Stratakos, I. Gerogianni, Z. Daniil, L. Kolilekas, K. Dimakou, G. Pitsidianakis, N. Tzanakis, S. Tryfon, F. Fragopoulos, E.M. Antonogiannaki, A. Lazaratou, E. Fouka, D. Papakosta, P. Emmanouil, N. Anagnostopoulos, T. Karampitsakos, K. Vlami, M. Kallieri, P. Lyberopoulos, S. Loukides, D. Bouros, A. Bush, M. Balduyck, C. Lombard, V. Cottin, J.F. Mornex, C.F. Vogelmeier, T. Greulich, E.D. Manali   +37 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Object orientation without extending Z

, 2002
The good news of this paper is that without extending Z, we can elegantly specify object-oriented systems, including encapsulation, inheritance and subtype polymorphism (dynamic dispatch).
Mark Utting, Shaochun Wang, Utting, Mark, Wang, Shaochun   +3 more
core   +1 more source

Assessment of the impact of Z-Spring appliances and clear aligners on salivary parameters and periodontal health in children: a randomized clinical trial

BMC Oral Health
Background Removable appliances greatly affect oral hygiene and increase the amount of plaque retention. The aim of this prospective study was to evaluate the effects of anterior crossbite treatment with Z-spring appliance and clear aligners on ...
İrem Kapici, Ahmet Yalcin Gungor, Ozge Erken Gungor   +2 more
doaj   +1 more source

Alterations in maternal cardiovascular parameters and their impact on uterine and fetal circulation in hypertensive pregnancies and fetal growth restriction

International Journal of Cardiology. Cardiovascular Risk and Prevention
Objective: To examine potential alterations in maternal cardiovascular parameters in hypertensive pregnancies with or without fetal growth restriction (FGR) in comparison to uncomplicated normotensive pregnancies, and to determine the correlation between
Tatjana Maseliene, Guoda Zukiene, Anna Laurinaviciene, Dalia Breskuviene, Diana Ramasauskaite, Vilma Dzenkeviciute   +5 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source