Results 211 to 220 of about 238,587 (230)

Pi*S and Pi*Z alpha 1 antitrypsin polymorphism and the risk for asbestosis in occupational exposure to asbestos

Toxicology Letters, 2002
Alpha 1 antitrypsin is a highly polymorphic anti-elastase enzyme, especially active in the protection of alveoli and liver. Here we studied the distribution of two deficient alleles Pi*Z and Pi* S, in 194 asbestos workers, of whom 100 were asbestosis cases, and 94 were controls without disease (exposed controls, EC).
M J, Lafuente, X, Casterad, N, Laso, S, Mas, R, Panades, A, Calleja, S, Hernandez, D, Turuguet, A, Ballesta, C, Ascaso, A, Lafuente   +10 more
openaire   +2 more sources

THE Pi Z ALLELE AND AND HEPATIC ALPHA₁‐ANTITRYPSIN GLOBULES IN PATIENTS WITH SECONDARY LIVER CANCER

Acta Pathologica Microbiologica Scandinavica Series A :Pathology, 1986
To evaluate the frequency of false positive globular inclusions, 89 autopsy cases with various malignancies and liver metastases have been examined by immunoperoxidase staining of liver sections and isoelectric focusing of sera. Four subjects with AAT globules in their hepatocytes were found, all of whom had the Pi Z phenotype. Globular inclusions were
I, Reintoft, I, Hägerstrand
openaire   +2 more sources

Segregation distortion of the alpha 1-antitrypsin Pi Z allele.

American journal of human genetics, 1979
alpha 1-antitrypsin (alpha 1AT) of the Pi type Z is associated with two diseases: pulmonary emphysema and cirrhosis of the liver. We report 23 families with both parents heterozygous for the PiZ allele, characterized from our own analysis and from world literature sources. All families were identified through members expressing disease.
R M, Iammarino, D K, Wagener, R C, Allen
openaire   +1 more source

Natural History and Life Expectancy in Severe Alpha₁‐Antitrypsin Deficiency, Pi Z

Acta Medica Scandinavica, 1978
ABSTRACT. Clinical data from 246 adult Swedish individuals with severe α1‐antitrypsin deficiency, Pi Z, diagnosed in 1963‐77, were analyzed. Primary emphysema was present in 109 cases. Of 75 Pi Z patients with other types of chronic obstructive pulmonary disease (COPD), all but 7 showed signs of emphysema.
openaire   +2 more sources

DNA restriction fragments associated with α1-antitrypsin indicate a single origin for deficiency allele PI Z

Nature, 1985
The alpha 1-protease inhibitor, or alpha-antitrypsin (AAT), a major plasma inhibitor of leukocyte elastase and bacterial proteases, is encoded at the PI locus on chromosome 14 (14q24.3-q32.1). A deficiency of AAT in individuals homozygous for the PI Z allele occurs in about 1 in 2,000-8,000 caucasians and is associated with an increased risk of early ...
D W, Cox, S L, Woo, T, Mansfield
openaire   +2 more sources

Absence of the alpha-1-antitrypsin PI*Z allele in Tunisia substantiates the particular genetic structure of African populations

American Journal of Human Biology, 1997
Alpha-1-antitrypsin (PI) phenotypes were studied in a sample of 450 Tunisians. The observed frequencies of PI alleles were identical to those in African populations, with a very low incidence of PI*S and virtual absence of PI*Z. Such figures are similar to estimates in Asians and clearly opposite to those in Europeans. Am. J. Hum. Biol. 9:223-224, 1997.
S, Makni, M, Zitouni, K, Ayed, S, Mhirii, S, Azabi, F, Cherif, M, Maalej, J P, Martin, R, Sesboüé   +8 more
openaire   +2 more sources

High-Speed Detection of α1-Antitrypsin Deficiency Alleles Pi*S and Pi*Z on the LightCycler

2001
Protease inhibitor 1 (αl-antitrypsin, AT) is the main serum inhibitor of proteolytic enzymes. In AT-deficiency, enzymes such as neutrophil elastase can damage the lung tissues, leading to pulmonary emphysema. More than 90 different alleles have been identified so far for the protease inhibitor 1 (PI) gene.
Charalampos Aslanidis, Gerd Schmitz
openaire   +1 more source

Familial alpha-1-antitrypsin dificiency with Pi-Z and a new Pi-Gcler variant.

Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1981
A case of familial deficiency in alpha-1-antitrypsin connected with Pi-0Z gene led to the finding of a new Gcler variant partly deficient, the electrofocusing pattern of which, located between that of G and I variants, was modified after neuraminidase digestion.
M P, Plazonnet, J, Constans, G, Misson, C, Gentou   +3 more
openaire   +1 more source

Vlastela grada Dubrovnika 6. Odabrane biografije (Pi - Z)

2015
Knjiga obuhvaća biografije značajnih pripadnika dubrovačkih vlasteoskih rodova od slova Pi do Z.
openaire   +1 more source

Sa1540 THE IMPACT OF A1-ANTITRIPSIN DEFICIENCY AND PI*Z ALLELE IN LIVER FIBROSIS

Gastroenterology, 2023
Ana Isabel Ferreira, Tiago Lima Capela, Sofia Xavier, Joana Magalhães, Catarina Guimarães, Carla M. Marinho, José Cotter   +6 more
openaire   +1 more source