Results 111 to 120 of about 4,228,114 (275)
Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane +9 morewiley +1 more sourceDalitz Plot Analysis of B+- --> pi+-pi+-pi-+ Decays
, 2009 Comment: 16 pages, 8 postscript figures, published in Phys.B. Aubert, R. Barate, D. Boutigny, F. Couderc, Y. Karyotakis, J. P. Lees, V. Poireau, V. Tisserand, A. Zghiche, E. Grauges, A. Palano, M. Pappagallo, A. Pompili, J. C. Chen, N. D. Qi, G. Rong, P. Wang, Y. S. Zhu, G. Eigen, I. Ofte, B. Stugu, G. S. Abrams, M. Battaglia, A. B. Breon, D. N. Brown, J. Button Shafer, R. N. Cahn, M. S. Gill, A. V. Gritsan, Y. Groysman, R. G. Jacobsen, J. Kadyk, L. T. Kerth, Y.u. G. Kolomensky, G. Kukartsev, G. Lynch, L. M. Mir, P. J. Oddone, T. J. Orimoto, N. A. Roe, M. T. Ronan, W. A. Wenzel, M. Barrett, K. E. Ford, T. J. Harrison, A. J. Hart, C. M. Hawkes, B. Lewandowski, M. Pelizaeus, K. Peters, T. Schroeder, T. Cuhadar Donszelmann, B. G. Fulsom, C. Hearty, N. S. Knecht, T. S. Mattison, J. A. McKenna, A. Khan, P. Kyberd, M. Saleem, L. Teodorescu, A. E. Blinov, V. E. Blinov, A. D. Bukin, V. P. Druzhinin, V. B. Golubev, E. A. Kravchenko, A. P. Onuchin, S. I. Serednyakov, Y. I. Skovpen, E. P. Solodov, D. Best, M. Bondioli, M. Bruinsma, M. Chao, I. Eschrich, D. Kirkby, A. J. Lankford, M. Mandelkern, B. L. Hartfiel, S. D. Foulkes, J. W. Gary, O. Long, B. C. Shen, K. Wang, L. Zhang, D. del Re, H. K. Hadavand, E. J. Hill, D. B. MacFarlane, H. P. Paar, J. W. Berryhill, C. Campagnari, A. Cunha, M. A. Mazur, J. D. Richman, W. Verkerke, T. W. Beck, A. M. Eisner, C. J. Flacco, C. A. Heusch, J. Kroseberg, W. S. Lockman, G. Nesom, T. Schalk, B. A. Schumm, A. Seiden, P. Spradlin, D. C. Williams, M. G. Wilson, J. Albert, G. P. Dubois Felsmann, A. Dvoretskii, D. G. Hitlin, I. Narsky, T. Piatenko, F. C. Porter, A. Ryd, A. Samuel, R. Andreassen, S. Jayatilleke, G. Mancinelli, B. T. Meadows, M. D. Sokoloff, F. Blanc, P. Bloom, S. Chen, W. T. Ford, U. Nauenberg, A. Olivas, P. Rankin, W. O. Ruddick, J. G. Smith, K. A. Ulmer, S. R. Wagner, J. Zhang, A. Chen, E. A. Eckhart, A. Soffer, W. H. Toki, R. J. Wilson, Q. Zeng, D. Altenburg, E. Feltresi, A. Hauke, B. Spaan, T. Brandt, J. Brose, H. M. Lacker, R. Nogowski, S. Otto, A. Petzold, G. Schott, J. Schubert, K. R. Schubert, R. Schwierz, J. E. Sundermann, D. Bernard, G. R. Bonneaud, C. Thiebaux, G. Vasileiadis, M. Verderi, D. J. Bard, P. J. Clark, W. Gradl, F. Muheim, S. Playfer, Y. Xie, M. Andreotti, V. Azzolini, D. Bettoni, C. Bozzi, R. Calabrese, G. Cibinetto, E. Luppi, M. Negrini, L. Piemontese, F. Anulli, R. Baldini Ferroli, A. Calcaterra, R. de Sangro, G. Finocchiaro, P. Patteri, I. M. Peruzzi, M. Piccolo, A. Zallo, A. Buzzo, R. Capra, R. Contri, M. Lo Vetere, M. Macri, M. R. Monge, S. Passaggio, C. Patrignani, E. Robutti, A. Santroni, S. Tosi, S. Bailey, E. Won, J. Wu, N. Arnaud, F. Di Lodovico, P. S. Jackson, G. D. Lafferty, C. Chen, C. Dallapiccola, F. Palombo, C. Sciacca, G. Raven, J. Strube, J. Ocariz, G. Calderini, M. Carpinelli, G. Marchiori, N. Neri, C. Voena, T. Adye, G. Hamel de Monchenault, G. Vasseur, D. Su, M. Bomben, L. Lanceri, S. Banerjee, R. Kowalewski, J. M. Roney, T. E. Latham, S. L. Wu +226 moreopenaire +5 more sourcesBridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme +8 morewiley +1 more sourceIn vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni +14 morewiley +1 more sourceAmplitude Analysis of B -> pi pi pi and B -> K pi pi
, 2004 We present preliminary results of a maximum-likelihood Dalitz-plot analysis of the charmless hadronic B decays to the final states pi pi pi and K pi pi from data corresponding to an integrated on-resonance luminosity of 166 fb^-1 recorded by the BABAR experiment at the SLAC PEP-II asymmetric-energy B Factory.Aubert, B., Collaboration, BABARopenaire +1 more sourceInhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge +18 morewiley +1 more sourceA synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more source