Results 121 to 130 of about 4,228,114 (275)
Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourceIncentives for Better Performance in Health Care
Sultan Qaboos University Medical Journal, 2011 Incentives for better performance in health care have several modes and methods. They are designed to motivate and encourage people to perform well and improve their outcomes.Asaad Abduljawad, Assaf F. Al-Assafdoaj Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourcePredictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more sourceFeasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis +11 morewiley +1 more sourceStudy of B0 -> D*- pi+ pi- pi+ and B0 -> D*- K+ pi- pi+ decays
, 2013 Comment: 12 pages, 2 ...LHCb collaboration, Aaij, R., Beteta, C. Abellan, Adametz, A., Adeva, B., Adinolfi, M., Adrover, C., Affolder, A., Ajaltouni, Z., Albrecht, J., Alessio, F., Alexander, M., Ali, S., Alkhazov, G., Cartelle, P. Alvarez, Alves Jr, A. A., Amato, S., Amhis, Y., Anderlini, L., Anderson, J., Andreassen, R., Appleby, R. B., Gutierrez, O. Aquines, Archilli, F., Artamonov, A., Artuso, M., Aslanides, E., Auriemma, G., Bachmann, S., Back, J. J., Baesso, C., Balagura, V., Baldini, W., Barlow, R. J., Barschel, C., Barsuk, S., Barter, W., Bauer, Th., Bay, A., Beddow, J., Bediaga, I., Belogurov, S., Belous, K., Belyaev, I., Ben-Haim, E., Benayoun, M., Bencivenni, G., Benson, S., Benton, J., Berezhnoy, A., Bernet, R., Bettler, M. -O., van Beuzekom, M., Bien, A., Bifani, S., Bird, T., Bizzeti, A., Bjørnstad, P. M., Blake, T., Blanc, F., Blanks, C., Blouw, J., Blusk, S., Bobrov, A., Bocci, V., Bondar, A., Bondar, N., Bonivento, W., Borghi, S., Borgia, A., Bowcock, T. J. V., Bowen, E., Bozzi, C., Brambach, T., Brand, J. van den, Bressieux, J., Brett, D., Britsch, M., Britton, T., Brook, N. H., Brown, H., Burducea, I., Bursche, A., Buytaert, J., Cadeddu, S., Callot, O., Calvi, M., Gomez, M. Calvo, Camboni, A., Campana, P., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carranza-Mejia, H., Carson, L., Akiba, K. Carvalho, Casse, G., Cattaneo, M., Cauet, Ch., Charles, M., Charpentier, Ph., Chen, P., Chiapolini, N., Chrzaszcz, M., Ciba, K., Vidal, X. Cid, Ciezarek, G., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Coca, C., Coco, V., Cogan, J., Cogneras, E., Collins, P., Comerma-Montells, A., Contu, A., Cook, A., Coombes, M., Coquereau, S., Corti, G., Couturier, B., Cowan, G. A., Craik, D., Cunliffe, S., Currie, R., D'Ambrosio, C., David, P., David, P. N. Y., De Bonis, I., De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J. M., De Paula, L., De Silva, W., De Simone, P., Decamp, D., Deckenhoff, M., Degaudenzi, H., Del Buono, L., Deplano, C., Derkach, D., Deschamps, O., Dettori, F., Di Canto, A., Dickens, J., Dijkstra, H., Dogaru, M., Bonal, F. Domingo, Donleavy, S., Dordei, F., Suárez, A. Dosil, Dossett, D., Dovbnya, A., Dupertuis, F., Dzhelyadin, R., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., van Eijk, D., Eisenhardt, S., Eitschberger, U., Ekelhof, R., Eklund, L., Rifai, I. El, Elsasser, Ch., Elsby, D., Falabella, A., Färber, C., Fardell, G., Farinelli, C., Farry, S., Fave, V., Ferguson, D., Albor, V. Fernandez, Rodrigues, F. Ferreira, Ferro-Luzzi, M., Filippov, S., Fitzpatrick, C., Fontana, M., Fontanelli, F., Forty, R., Francisco, O., Frank, M., Frei, C., Frosini, M., Furcas, S., Furfaro, E., Torreira, A. Gallas, Galli, D., Gandelman, M., Gandini, P., Gao, Y., Garofoli, J., Gersabeck, E., Gligorov, V. V., Graugés, E., He, J., Hoballah, M., Koppenburg, P., Lafferty, G., Latham, T., Gac, R. Le, Lefèvre, R., Leroy, O., Martinelli, M., Santos, D. Martinez, Massafferri, A., Nasteva, I., Needham, M., Orlandea, M., Parkinson, C. J., Perazzini, S., Perrin-Terrin, M., Petrolini, A., Phan, A., Casasus, M. Plo, Poluektov, A., Potterat, C., Navarro, A. Puig, Rangel, M. S., Raven, G., Rodrigues, E., Sarti, A., Schiller, M., Schmelling, M., Schneider, O., Sciascia, B., Serra, N., Serrano, J., Seyfert, P., Shears, T., Souza, D., Steinkamp, O., Stone, S., van Tilburg, J., Tisserand, V., Tonelli, D., Gomez, R. Vazquez, Regueiro, P. Vazquez, Watson, N. K., Yang, Z., Zhang, Y. +248 moreopenaire +4 more sourcesThe neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal +8 morewiley +1 more sourceGlycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala +18 morewiley +1 more source
