Results 131 to 140 of about 231,101 (299)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Reflectance spectra from a white staminate-phase flower, Pinkness Index (PI) = 0.0764 (A) and a pink pistillate-phase flower, PI = 0.4896 (B) of Saponaria officinalis.

, 2014
Reflectance spectra from a white staminate-phase flower, Pinkness Index (PI) = 0.0764 (A) and a pink pistillate-phase flower, PI = 0.4896 (B) of Saponaria officinalis.
Sandra L. Davis (545643), Michael M. Britton (545649), Leah M. Freestone (545646), Dana A. Dudle (545644), Jenna R. Nawrocki (545645), Michael B. Tobin (545648), Peter Konieczny (545647)   +6 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Gestational age (GA)-specific longitudinal reference centiles for ductus venosus pulsatility index (DV-PI).

, 2019
Gestational age (GA)-specific longitudinal reference centiles for ductus venosus pulsatility index (DV-PI).
Maria Angela Rustico (8098529), Marcella Pellegrino (8098520), Irene Cetin (278111), Daniela Casati (555037), Ivan Cortinovis (18378), Elena Spada (375160), Stefano Faiola (8098526), Mariano Lanna (8098523)   +7 more
core   +1 more source

Effect of perfusion index on oxygen reserve index accuracy in estimating arterial oxygen tension in anesthetized dogs: Data reanalysis.

PLoS ONE
Multi-wave CO-oximetry, utilizing the oxygen reserve index (ORi), estimates arterial partial pressure of oxygen (PaO2) in mild hyperoxemia, between 100 and 200 mmHg, and concurrently quantifies local perfusion at the measurement site using the perfusion ...
Francesca Zanusso, Luca Bellini
doaj   +1 more source

Parametrial involvement in cervical cancer is associated with systemic inflammatory indices: a retrospective observational study

Frontiers in Medicine
ObjectiveThe aim of this study is to evaluate the association between parametrial invasion (PI) and systemic inflammatory indices in patients with cervical cancer, exploring whether routinely available hematological markers reflect local tumor spread ...
Carlo Ronsini, Antonino Di Nuzzo, Antonino Di Nuzzo, Giuseppe Cucinella, Maria Cristina Solazzo, Eva Iannacone, Federica Gherardi, Vito Chiantera, Vito Chiantera   +8 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Vertex and edge PI indices of Cartesian product graphs

, 2007
The Padmakar–Ivan (PI) index of a graph G is the sum over all edges uv of G of the number of edges which are not equidistant from u and v. In this paper, the notion of vertex PI index of a graph is introduced.
M.H. Khalifeh, Yousefi-Azari, H., Ashrafi, A.R., Khalifeh, M.H., H. Yousefi-Azari, A.R. Ashrafi   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source