Results 241 to 250 of about 4,754,290 (301)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Relationship between peri-implant soft tissue characteristics and peri-implant health and mucositis: a cross-sectional study. [PDF]

Saudi Dent J
Sahin T, Eezammuddeen NBN.
europepmc   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Uterine artery hemodynamic parameters as key predictors of missed abortion risk: clinical validation based on a multimodal predictive model. [PDF]

Am J Transl Res
Dong X, Liu Y, Wang X, Li N.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Lumbar Sympathetic Radiofrequency Ablation for Peripheral Arterial Disease: Considerations Regarding Patient Selection and Interpretation of Short-Term Outcomes [Letter]. [PDF]

J Pain Res
Çelik G.
europepmc   +1 more source

Could Perfusion and Pleth Variability Index Be Useful in Managing Treatment and Morbidity in Patients with Gastrointestinal Bleeding? [PDF]

J Clin Med
Atasoy H, Karabacak IM, Keklikkiran C, Gumus A, Konur K.   +4 more
europepmc   +1 more source

The predictive value of abnormal uteroplacental and fetal Doppler indices for adverse perinatal outcomes in hypertensive disorders of pregnancy: a systematic review and meta-analysis. [PDF]

Front Med (Lausanne)
Zhou P, Tang Z, Li S, Zhang W, Song J, Gao F, Yang L.   +6 more
europepmc   +1 more source