Results 71 to 80 of about 231,101 (299)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Correlation between TNF-α and phagocytosis index (PI).
, 2013 Correlation between TNF-α and phagocytosis index (PI).
Fábio T. M. Costa (5654905) +9 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Evaluation of Drought Tolerance in Safflower Genotypes Based on Drought Tolerance indices
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2014 Among the different environmental stresses, drought is the constraint that induces a highly negative effect on crop production. In order to identify drought tolerant genotypes, an experiment was conducted in a randomized complete block design with three ...
Marouf KHALILI +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
ON THE PI INDEX: PI-PARTITIONS AND CARTESIAN PRODUCT GRAPHS
, 2006 PI index is an edge-additive topological index introduced as a counterpart to the vertexmultiplicative Szeged index. In this paper PI-partitions are introduced and used to simplify the computation of the PI-index on those graph that admit nontrivial PI ...
Sandi Klavzar
core
, 2015 In this study, we base on historical flood/drought records to reconstruct (A) PIA and (B) PIB. We subtract PIB from PIA to give (C) the IRPV index. All of the above indices are in decadal units and spanned AD580–1979 (see Section 2.1).
Qing Pei (585963) +3 more
core +1 more source
Current OncologyBackground: MRI fusion prostate biopsy has improved the detection of clinically significant prostate cancer (CSC). Continued refinements in predicting the pre-biopsy probability of CSC are essential for optimal patient counseling.
Ahmad N. Alzubaidi +11 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source