Results 51 to 60 of about 565,619 (298)

Preservation of glaciochemical time-series in snow and ice from the Penny Ice Cap, Baffin Island [PDF]

, 1998
A detailed investigation of major ion concentrations of snow and ice in the summit region of Penny Ice Cap (PIC) was performed to determine the effects of summer melt on the glaciochemical time-series.
Fisher, David, Grumet, Nancy S, Jacobs, John D, Koerner, Roy M, Wake, Cameron P, Zielinski, Gregory A   +5 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Estimating genetic parameters of digital behavior traits and their relationship with production traits in purebred pigs

Genetics Selection Evolution
Background With the introduction of digital phenotyping and high-throughput data, traits that were previously difficult or impossible to measure directly have become easily accessible, offering the opportunity to enhance the efficiency and rate of ...
Mary Kate Hollifield, Ching-Yi Chen, Eric Psota, Justin Holl, Daniela Lourenco, Ignacy Misztal   +5 more
doaj   +1 more source

Integration of the Barcelona Supercomputing Center for CMS computing: Towards large scale production [PDF]

EPJ Web of Conferences
The CMS experiment is working to integrate an increasing number of High Performance Computing (HPC) resources into its distributed computing infrastructure.
Acosta-Silva C., Delgado Peris A., Flix Molina J., Hernández J.M., Pérez-Calero Yzquierdo A., Pineda Sánchez E., Villalonga Domínguez I.   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Comparative analysis of Machine Learning-based eviction techniques and LRU mechanisms for CMS data caching [PDF]

EPJ Web of Conferences
The Large Hadron Collider (LHC) at CERN in Geneva is preparing for a major upgrade that will improve both its accelerator and particle detectors. This strategic move comes in anticipation of a tenfold increase in proton-proton collisions, expected to ...
Delgado Peris A., Flix Molina J., Hernández J.M., Pérez-Calero Yzquierd A., Rodríguez Calonge F.J., Serrano P., Sikora A., Vilalta J.   +7 more
doaj   +1 more source

AN ULTRA-FAINT GALAXY CANDIDATE DISCOVERED in EARLY DATA from the MAGELLANIC SATELLITES SURVEY [PDF]

, 2016
We report a new ultra-faint stellar system found in Dark Energy Camera data from the first observing run of the Magellanic Satellites Survey (MagLiteS).
Bechtol K., Bertin E. ed Evans I. N., Bertin E. ed Gabriel C., Besla G., Busha M. T., Chabrier G., Dotter A., Drlica-Wagner A., D’Onghia E., Foreman-Mackey D., Kallivayalil N., Kim D., Koposov S. E., Koposov S. E., Laevens B. P. M., Laevens B. P. M., Majewski S. R., Martin N. F., Martin N. F., Muñoz R. R., Nichols M., Nidever D. L., Nidever D. L., Saha A., Sales L. V., Sand D. J., Schlafly E. F., Schlegel D. J., Sevilla I., Tucker D. L., van der Marel R. P., Walker M. G., Zacharias N.   +32 more
core   +6 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Autonomous Underwater Navigation and Optical Mapping in Unknown Natural Environments

Sensors, 2016
We present an approach for navigating in unknown environments while, simultaneously, gathering information for inspecting underwater structures using an autonomous underwater vehicle (AUV).
Juan David Hernández, Klemen Istenič, Nuno Gracias, Narcís Palomeras, Ricard Campos, Eduard Vidal, Rafael García, Marc Carreras   +7 more
doaj   +1 more source

Genetic and phenotypic time trends of litter size, piglet mortality, and birth weight in pigs

Frontiers in Animal Science, 2023
IntroductionLitter size in pigs has increased steadily since 1990. Because of unfavorable genetic correlations with piglet mortality, breeding goals should include survival traits next to litter size.
Pieter W. Knap, Egbert F. Knol, A. Christian Sørensen, Abe E. Huisman, Dianne van der Spek, Louisa J. Zak, Ana Granados Chapatte, Craig R. G. Lewis   +7 more
doaj   +1 more source