Results 61 to 70 of about 116,173 (293)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2017 Introdução: A obesidade é uma doença crônica multifatorial, que promove comorbidades importantes desencadeando grande repercussão à saúde. Porém, quando instalada e diante do insucesso de formas conservadoras de tratamento, a gastroplastia é indicada ...
Dora Castro Agulhon Segura +4 more
doaj
CABI Agriculture and Bioscience, 2022 The selection and introduction of disease resistance genes in livestock not only provide health benefits to animals but opportunities for breeders and farmers to meet the growing demand for high-quality meat and milk while reducing agriculture’s ...
A. Mark Cigan, Pieter W. Knap
doaj +1 more source
, 2023 Dalam rangka meningkatkan mutu pelayanan dosen khususnya Tridarma perguruan tinggi diperlukan pengakuan kinerja sehingga dosen yang bersangkutan dapat meningkatkan kinerjanya.
openaire +1 more source
Advanced fluid modeling and PIC/MCC simulations of low-pressure ccrf discharges [PDF]
, 2016 Comparative studies of capacitively coupled radio-frequency discharges in helium and argon at pressures between 10 and 80 Pa are presented applying two different fluid modeling approaches as well as two independently developed particle-in-cell/Monte ...
M. Becker +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Effect of pooled tracheal sample testing on the probability of Mycoplasma hyopneumoniae detection
Scientific ReportsTracheal pooling for Mycoplasma hyopneumoniae (M. hyopneumoniae) DNA detection allows for decreased diagnostic cost, one of the main constraints in surveillance programs.
Ana Paula Serafini Poeta Silva +13 more
doaj +1 more source
A Naturologia no Brasil: histórico, contexto, perfil e definições
Horizonte, 2018 Resenha: STERN, Fábio Leandro. A Naturologia no Brasil: histórico, contexto, perfil e definições. São Paulo: Entre Lugares, 2017. 447p. ISBN 978-89-7326-343-1 A editora Entre Lugares estreou em 2017 com uma obra de qualidade exemplar: trata-se do livro
Matheus Oliva da Costa
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source