Results 111 to 120 of about 143,337 (259)
VIEW, EarlyView.We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen +9 more
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PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer’s disease
Scientific ReportsWe examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer’s disease and synaptic integrity. Publicly available datasets (BRAINEAC, ROSMAP, ADC1) and a cohort of asymptomatic but “at risk” individuals (PREVENT-
Alexandre Poirier +9 more
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Does Proactivity Affect Insurance Solidarity and Individual Responsibility?
The British Journal of Sociology, EarlyView.ABSTRACT Over the past 20 years, the insurance industry has been experimenting with technological innovations that deeply affect its business model and social function. This article explores the use of digital technologies to monitor policyholders' behaviour and personalise their insurance coverage.
Alberto Cevolini, Elena Esposito
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Picard Groups of Stacky Curves
, 2023 We describe the Picard group of a tame stacky curve as an extension of two groups, which depend on the gerbe class of the curve over its rigidification, a stacky curve with trivial generic stabilizer, and the residual gerbes of the rigidification. After presenting the general formulation, we compute some specific examples.
openaire +2 more sources
Insect Science, EarlyView.Coloration serves several fitness‐related functions, including thermoregulation, immunity, social signaling, sexual selection, and predator avoidance. Consequently, color polymorphism can have a significant impact on a species’ interactions with its environment, including its relationships with predators, prey, and potential mates. The wood tiger moth (
Juan A. Galarza +9 more
wiley +1 more source
Integrative Zoology, EarlyView.Museum specimens provide a rich source of historical DNA, enabling insights into phylogenetic relationships and demographic history of the endangered Koklass Pheasant. Our findings uncovered a previously unrecognized population in Guizhou province and highlighted elevated extinction risk in populations from Anhui province and Southern China, informing ...
Zhiyong Jiang +9 more
wiley +1 more source
Root, flow and order polytopes with connections to toric geometry
Forum of Mathematics, SigmaIn this paper, we study the class of polytopes which can be obtained by taking the convex hull of some subset of the points $\{e_i-e_j \ \vert \ i \neq j\} \cup \{\pm e_i\}$ in $\mathbb {R}^n$ , where $e_1,\dots ,e_n$ is the standard ...
Konstanze Rietsch +1 more
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Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model
Integrative Zoology, EarlyView.UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang +5 more
wiley +1 more source
Communications in Algebra, 2007 We introduce the Picard group of corings. We extend the well-known exact sequence from algebras and coalgebras over fields to corings. We extend the Aut-Pic property to corings and we give some new examples of corings having this property. Finally, we give the corresponding exact sequences for the category of entwined modules over an entwining ...
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Cryptorchidism: Novel genetic insights into CCDC149 mutations
Andrology, EarlyView.Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du +8 more
wiley +1 more source