Results 51 to 60 of about 143,337 (259)

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source

Dermatologic manifestations in paediatric neurofibromatosis type 2: a cross sectional descriptive multicentric study

Orphanet Journal of Rare Diseases, 2022
Background Neurofibromatosis type 2 (NF2) is characterized by bilateral vestibular schwannoma (VS) more often in adults but a severe paediatric form with multiple neurological tumours is also described.
S. Legoupil, D. Bessis, F. Picard, S. Mallet, J. Mazereeuw, A. Phan, D. Dupin-Deguine, M. Kalamarides, Research Group of the French Society of Paediatric Dermatology, C. Chiaverini   +9 more
doaj   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

On monodromy representation of period integrals associated to an algebraic curve with bi-degree (2,2)

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2017
We study a problem related to Kontsevich's homological mirror symmetry conjecture for the case of a generic curve Y with bi-degree (2,2) in a product of projective lines ℙ1 × ℙ1.
Tanabé Susumu
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Rapid investigation of BA.4/BA.5 cases in France

Frontiers in Public Health, 2022
AimWe aimed to describe the characteristics of individuals infected by BA.4 or BA.5 in France in comparison to BA.1, and analyze the factors associated with hospitalization among BA.4 and BA.5 cases.MethodsA standardized questionnaire was used to collect
Alain-Claude Kouamen, Helena Da Cruz, Mohamed Hamidouche, Anais Lamy, Anna Lloyd, Javier Castro Alvarez, Mathilde Roussel, Laurence Josset, Vincent Enouf, Charlotte Felici, Georges Dos Santos, Justine Schaeffer, Anna Maisa, Regional COVID-19 Investigation Group, Laboratory Group, Gwenola Picard, Vikpognon Michée Géraud, Alice Brembilla, Ellen Dahl, Souhaila Chent, Alizé Mercier, Gwladys Nadia Gbaguidi, Carine Grenier, Adeline Riondel, Huchet-Kervella Caroline, Bekheira Leila, Kemeny Stephan, Claire Vignault, Pauline Trémeaux, Pierre-Edouard Fournier, Sophie Vallet, Diane Descamps, Lionel Chollet, Nefert Dossou, Alice Moisan, Anais Soares, Marie Christine Jaffar Bandjee, Alexis de Rougement, Cécile Henquell, Anne Lavergne   +39 more
doaj   +1 more source

The Picard group of the loop space of the Riemann sphere

, 2010
The loop space of the Riemann sphere consisting of all C^k or Sobolev W^{k,p} maps from the circle S^1 to the sphere is an infinite dimensional complex manifold.
Mazet P., NING ZHANG, Palais R. S., Patyi I., Zhang N.   +4 more
core   +1 more source

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Some examples of Picard groups of blocks

, 2019
We calculate examples of Picard groups for 2-blocks with abelian defect groups with respect to a complete discrete valuation ring. These include all blocks with abelian 2-groups of 2-rank at most three with the exception of the principal block of J1.
Eaton, Charles W., Livesey, Michael
core   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source