Results 61 to 70 of about 143,337 (259)

Stacks of cyclic covers of projective spaces

, 2003
We define stacks of uniform cyclic covers of Brauer-Severi schemes, proving that they can be realized as quotient stacks of open subsets of representations, and compute the Picard group for the open substacks parametrizing smooth uniform cyclic covers ...
Arsie, Alessandro, Vistoli, Angelo
core   +2 more sources

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

A NIST-Traceable Lab-to-Sky Spectral and Radiometric Calibration for NASA’s High-Altitude Airborne Hyperspectral Pushbroom Imager for Cloud and Aerosol Research and Development (PICARD)

Remote Sensing
The Pushbroom Imager for Cloud and Aerosol Research and Development (PICARD) visible through shortwave infrared imaging spectrometer was developed to carry a calibration laboratory environment to high altitudes, while also providing high-dynamic-range ...
Gary D. Hoffmann, Thomas Ellis, Haiping Su, Alok Shrestha, Julia A. Barsi, Roseanne Dominguez, Eric Fraim, James Jacobson, Steven Platnick, G. Thomas Arnold, Kerry Meyer, Jessica L. McCarty   +11 more
doaj   +1 more source

Proprotein convertase subtilisin/kexin type 9 (PCSK9) in Alzheimer's disease: A genetic and proteomic multi-cohort study.

PLoS ONE, 2019
BackgroundProprotein convertase subtilisin/kexin type 9 (PCSK9) is a hepatic enzyme that regulates circulating low-density lipoprotein (LDL) cholesterol levels by binding to LDL receptors (LDLR) and promoting their degradation.
Cynthia Picard, Alexandre Poirier, Stéphanie Bélanger, Anne Labonté, Daniel Auld, Judes Poirier, PREVENT-AD Research Group   +6 more
doaj   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Copy number variations and founder effect underlying complete IL-10Rβ deficiency in Portuguese kindreds. [PDF]

PLoS ONE, 2018
Mutations in interleukin-10 receptor (IL-10R) genes are one cause of very early-onset inflammatory bowel disease with perianal lesions, which can be cured by hematopoietic stem cell transplantation.
Fabienne Charbit-Henrion, Bernadette Bègue, Anaïs Sierra, Sylvain Hanein, Marie-Claude Stolzenberg, Zhi Li, Sandra Pellegrini, Nicolas Garcelon, Marc Jeanpierre, Bénédicte Neven, Isabelle Loge, Capucine Picard, Jérémie Rosain, Jacinta Bustamante, Marc Le Lorc'h, Bénédicte Pigneur, Alicia Fernandes, GENIUS Group, Frédéric Rieux-Laucat, Jorge Amil Dias, Frank M Ruemmele, Nadine Cerf-Bensussan   +21 more
doaj   +1 more source

Picard Groups of Some Local Categories

Publications of the Research Institute for Mathematical Sciences, 2007
For each p -local spectrum E , \mathcal L_E denotes the full subcategory ...
Kamiya, Yousuke, Shimomura, Katsumi
openaire   +2 more sources

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Real structures on primary Hopf surfaces

Complex Manifolds
The first goal of this article is to give a complete classification (up to Real biholomorphisms) of Real primary Hopf surfaces (H,s)\left(H,s), and, for any such pair, to describe in detail the following naturally associated objects : the group Auth(H,s){
Khaled Zahraa
doaj   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source