Results 91 to 100 of about 698,086 (300)

PICO Portal

, 2021
PICO Portal is a Web-based systematic review management tool launched in September 2020 to better facilitate collaborative knowledge synthesis in biomedical research. Most notably, it uses machine learning and Natural Language Processing algorithms to continuously refine the screening process by analyzing decisions as made by the review team.
Minion, Joel T, Egunsola, Oluwaseun, Mastikhina, Liza, Farkas, Brenlea, Hofmeister, Mark, Flanagan, Jordyn, Salmon, Charleen, Clement, Fiona   +7 more
openaire   +1 more source

Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome‐Mediated Colitis and Mood Disorder

Advanced Science, EarlyView.
NLRP3 inflammasome contributes to colitis and mood disorder. This study demonstrates that neddylation targets NLRP3 at K287, which hinders its interaction with K48‐linked ubiquitination E3 Trim31 and thereby stabilizes it. Neddylation blockade in myeloid cells and microglia mitigates DSS‐induced colitis and psychological stress‐induced anxiety‐like ...
Wenbin Gai, Mengyao Wu, Anbiao Wu, Zhaofei Jing, Zhenjie Ye, Jiayan Jin, Yaolin Zhang, Min Zhao, Genyu Liu, Xu Wang, Xiqin Yang, Jie Dong, Yunlu Xu, Jiyan Zhang   +13 more
wiley   +1 more source

Microwave quantum diode

Nature Communications
The fragile nature of quantum circuits is a major bottleneck to scalable quantum applications. Operating at cryogenic temperatures, quantum circuits are highly vulnerable to amplifier backaction and external noise.
Rishabh Upadhyay, Dmitry S. Golubev, Yu-Cheng Chang, George Thomas, Andrew Guthrie, Joonas T. Peltonen, Jukka P. Pekola   +6 more
doaj   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

In Situ Polymer-Solution-Processed Graphene–PDMS Nanocomposites for Application in Intracranial Pressure Sensors

Nanomaterials
Polydimethylsiloxane (PDMS) has emerged as a promising candidate for the dielectric layer in implantable sensors due to its exceptional biocompatibility, stability, and flexibility.
Hua Hong, Junjie Zhang, Yuchen Zhu, Stephen D. Tse, Hongxuan Guo, Yilin Lai, Yubo Xi, Longbing He, Zhen Zhu, Kuibo Yin, Litao Sun   +10 more
doaj   +1 more source

Los avisos clasificados en la prensa de la ciudad de Bogotá: Continuidades y rupturas de la Colonia a la república [PDF]

, 2016
Este artículo pretende como meta examinar las características y alcances de los avisos clasificados publicados en la prensa de la ciudad de Bogotá entre 1801 y 1825 a través de un análisis comparativo entre el Correo Curioso de Santafé de Bogotá y la ...
Pita Pico, Roger
core  

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Electrically driven cation exchange for in situ fabrication of individual nanostructures

Nature Communications, 2017
Cation exchange, traditionally driven by ion solvation or thermal activation, is a robust approach for preparing heterogeneous nanostructures but lacks selectivity for preparation of individual nanocrystals.
Qiubo Zhang, Kuibo Yin, Hui Dong, Yilong Zhou, Xiaodong Tan, Kaihao Yu, Xiaohui Hu, Tao Xu, Chao Zhu, Weiwei Xia, Feng Xu, Haimei Zheng, Litao Sun   +12 more
doaj   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Peoples without religion: the fallacy of Valladolid controversy [PDF]

, 2016
De la multicitada controversia de Valladolid sobre la humanidad de los indios sabemos realmente muy poco debido a la falta de fuentes y documentos. Sin embargo, se ha convertido con el paso del tiempo en un referente historiográfico fundamental para ...
Montañez Pico, Daniel
core